ABSTRACT
Frontal recess anatomy can be very complex, with accessory cells, such as frontal bulla, agger nasi, suprabulla, and frontal ethmoidal (Kuhn) cells, which may lead to obstruction of the frontal sinus. Digital volume tomography of paranasal sinuses used in this investigation revealed the rate of types of development of various anatomic structures and their correlation with frontal sinusitis in patients with (a study) and without the latter (a control group).
Subject(s)
Cone-Beam Computed Tomography/methods , Frontal Sinus/diagnostic imaging , Frontal Sinusitis/diagnostic imaging , Adolescent , Adult , Aged , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Reproducibility of Results , Young AdultABSTRACT
Two carotene-containing drugs (natural and artificial) were shown to decrease the rate of chromosomal aberrations, induced by cyclophosphane, in bone marrow cells of mice, daily ration of which contained 10-20 mg/kg of beta-carotene within 1-3 weeks. The rate of chromosomal aberrations induced was decreased 1.5-2-fold in various experiments. Artificial beta-carotene exhibited aftereffect within at least 3 days, while its protective effect was decreased about by 20% within 7 days after administration.
Subject(s)
Antimutagenic Agents/pharmacology , Carotenoids/pharmacology , Animals , Antimutagenic Agents/chemistry , Bone Marrow/drug effects , Carotenoids/analysis , Carotenoids/chemistry , Chromosome Aberrations , Cyclophosphamide/toxicity , Male , Mice , Mice, Inbred CBA , Plant Extracts/chemistry , Plant Extracts/pharmacology , beta CaroteneABSTRACT
Development of spontaneous hepatomas was studied in CBA mice, which were maintained on a diet containing the carotenoid drug lipochromine in a dose of 25 mg/kg during their life beginning at the age of 3 months twice a week. Concentrations of vitamin A (as retinol) and beta-carotene were estimated in mice blood and liver tissue by means of HPLC. Decrease in occurrence of spontaneous tumors in liver tissue as well as distinct increase in periods of their development were detected in the animals treated with the drug. The phenomenon observed correlated positively with an increase in concentration of beta-carotene in liver tissue of tumor-bearing mice, thus indicating the preventive effect of lipochromine on spontaneous carcinogenesis in mice CBA strain.
