Subject(s)
Hypertension/physiopathology , Kidney/physiopathology , Adrenergic beta-Antagonists/therapeutic use , Adult , Ambulatory Care , Benzothiadiazines , Diuretics , Drug Therapy, Combination , Female , Follow-Up Studies , Humans , Hypertension/drug therapy , Male , Middle Aged , Sodium Chloride Symporter Inhibitors/therapeutic use , Vasodilator Agents/therapeutic useABSTRACT
Simultaneous study of renin activity and aldosterone concentration in the blood plasma of 180 out-patients with hypertensive disease has shown that persons with normal or increased reninemia predominate in the I stage of disease. Moderate positive correlation was observed between the level of aldosterone and renin activity; aldosterone-renin index at the stage of the disease remains unchanged. In stage II of hypertensive disease renin activity diminishes and the concentration of aldosterone in blood plasma rises, aldosteronerenin index is enhanced at the expense of aldosterone predominance, which is most often seen in the sub-group of patients with low reninemia. Aldosterone-renin index correlates positively with the duration of hypertensive disease.
