ABSTRACT
Well-differentiated fetal adenocarcinoma (WDFA), also known as low grade adenocarcinoma of the fetal lung type, is a rare pulmonary neoplasm now considered to be a variant of lung adenocarcinoma rather than a type of pulmonary blastoma. Upregulation of the Wnt signaling pathway with subsequent aberrant nuclear/cytoplasmic beta-catenin expression has been recently described in these tumors providing a possible pathogenetic role for this gene in WDFA. We describe the cytomorphologic findings of a case of WDFA in a 36-yr-old female patient and emphasize the diagnostic utility of aberrant nuclear/cytoplasmic expression of beta-catenin as an adjunct to the correct preoperative recognition of this tumor on aspiration cytology.
Subject(s)
Adenocarcinoma/pathology , Lung Neoplasms/pathology , beta Catenin/analysis , Adenocarcinoma/chemistry , Adenocarcinoma/surgery , Adult , Biomarkers, Tumor/analysis , Biopsy, Fine-Needle , Carcinoid Tumor/pathology , Carcinoma/secondary , Cell Nucleus/chemistry , Cell Nucleus/pathology , Colorectal Neoplasms/secondary , Cytoplasm/chemistry , Cytoplasm/pathology , Diagnosis, Differential , Endometrial Neoplasms/secondary , Female , Humans , Lung Neoplasms/chemistry , Lung Neoplasms/surgery , Pulmonary Blastoma/chemistry , Pulmonary Blastoma/pathologyABSTRACT
BACKGROUND: Extraskeletal myxoid chondrosarcoma is a rare tumor that has been reported and discussed in neurosurgical, orthopedic, and otolaryngologic literature. We report a case of vulvar extraskeletal myxoid chondrosarcoma. CASE: This is a case of a 46-year-old woman who presented with a soft tissue mass in the left vulva and underwent local excision. Grossly, the tumors appeared to be leiomyomas. Pathology revealed an extraskeletal myxoid chondrosarcoma. CONCLUSION: We report the first case of an extraskeletal myxoid chondrosarcoma arising in the vulva.
