ABSTRACT
We have analysed the available worlds scientific literature concerning chronotherapy of malignant neoplasms of different localization. The review is focused on the results of multicenter investigations into this problem organized by the chronotherapy group in the framework of EORTC that have demonstrated a higher antiblastoma activity and improved tolerability of preparations applied in the chronomodulated regimen in comparison with the traditional treatment. Our original observations and recommendations ensuing from our many-year experience with the use of chemo- and radiotherapy of rectal and cervical cancer in the optimal time of day for the normal tissues constitute a basis for the more extensive introduction of chronobiological techniques to clinical practice.
