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[The immunomodulating properties of the diuretic bufenoks]. / Immunomoduliruiushchie svoistva diuretika bufenoksa.
Romanova, T V; Prokina, V V; Kolesnikova, O P; Kudaeva, O T; Kozlov, V A.
Biull Eksp Biol Med ; 114(10): 387-9, 1992 Oct.
Article in Russian | MEDLINE | ID: mdl-1288697

ABSTRACT

Bufenox, a diuretic with a sodium-uretic and light potassium--uretic effect, has an immediate but short-term effect, stimulates IgM antibody production, depressed delayed-type hypersensitivity. The immunomodulating effect of bufenox may be due to changes in Na+ ions concentrations since sodium load abrogates immunoactive properties of the drug.


Subject(s)
Adjuvants, Immunologic/pharmacology , Bumetanide/pharmacology , Adjuvants, Immunologic/administration & dosage , Animals , Antibody-Producing Cells/drug effects , Antibody-Producing Cells/immunology , Bumetanide/administration & dosage , Female , Hypersensitivity, Delayed/chemically induced , Hypersensitivity, Delayed/immunology , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Natriuresis/drug effects , Natriuresis/immunology , Potassium/urine , Spleen/drug effects , Spleen/immunology
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