ABSTRACT
A new hormonal preparation--Yuvemon (analog of methoprene)--insecticide for mosquito larvae was synthesized in USSR. LD50 for rat is 25,000 mg/kg. Safety of the preparation was demonstrated.
Subject(s)
Methoprene/analogs & derivatives , Methoprene/toxicity , Animals , Female , Lethal Dose 50 , Methoprene/administration & dosage , Rabbits , RatsABSTRACT
Proceeding from the experimental study carried out on the model of aniline methemoglobinemia, it was shown that the animals with low aniline-related resistance also had aniline low-resistant posterity during two following generations and vice versa high-resistant animals had the more aniline-resistant posterity. It was determined both by methemoglobin levels and by the number of animals with different methemoglobin levels. According to the degree of aniline-induced methemoglobinemia the correlation among three generations of animals was established.
Subject(s)
Aniline Compounds/toxicity , Disease Models, Animal , Drug Hypersensitivity/genetics , Methemoglobinemia/chemically induced , Parents , Prenatal Exposure Delayed Effects , Animals , Drug Resistance , Female , Male , Methemoglobinemia/genetics , Pregnancy , RatsABSTRACT
An experimental evaluation of the impact of a number of chemical compounds toxicologically attributed to different hazardous classes on animal resistibility to influenza virus showed that resistibility dependence on the dose and effect duration had a nonlinear character. There was no complete correlation of a hazardous class of chemical substances and their impact on body resistibility to respiratory infections.
Subject(s)
Ethylene Glycols/pharmacology , Formaldehyde/pharmacology , Lead/pharmacology , Orthomyxoviridae Infections/immunology , Animals , Dose-Response Relationship, Drug , Ethylene Glycols/administration & dosage , Formaldehyde/administration & dosage , Immunity, Innate/drug effects , Lead/administration & dosage , Mice , Orthomyxoviridae Infections/prevention & controlABSTRACT
The paper deals with the influence of 1-month pretreatment of mice with different regimes of long-wave UV-radiation on spontaneous and cyclophosphamide (CP) induced levels of chromosome aberrations in the bone marrow cells. The level of aberrant cells in the bone marrow of control and CP treated mice was not changed by the suberythematous dose (0.5 of the erythematous dose) of UV-radiation. The mice pretreatment with 3 erythematous doses of UV-radiation significantly increased spontaneous and CP induced level of cells with chromosome aberrations as compared with that in UV-unexposed mice.
