[Evaluation of the quality of mexiletine hydrochloride using capillary electrophoreses]. / Hodnotenie kvality hydrochloridu mexiletínu kapilárnou elektroforézou.

Mexiletine hydrochloride and its potential impurity xylenol were determined by micellar electrokinetic chromatography in a 25 cm long capillary. The effect of parameters--temperature, electric field, concentration of analyzed compounds, type and composition of background electrolyte--on the separation of analytes and precision of analysis was studied. The advantage of the elaborated method is a very short time of analysis (2.3 min) at the sufficient level of precision and reliability of results.

[Preparation and antineoplastic activity of acylhydrazones of R- and S-usnic acid]. / Príprava a protinádorové úcinky acylhydrazónov R- a S-usnovej kyseliny.

Hydrazones of R- and S-usnic acid were prepared by condensation of the appropriate enantiomer of usnic acid with hydrazides of aromatic acids. Prepared compounds were characterized by spectral methods. Reaction kinetic was studied with capillary electrokinetic chromatography, enantiomeric purity of products was checked by capillary electrophoresis in the presence of gamma-cyclodextrin. Obtained hydrazones were tested as prospective antimitotic agents. The antitumor activity was screened in vitro on human tumor cell lines. The overall activity of tested compounds was low, however, the R- enantiomers were more active than their opposite stereoisomers.