[Effect of acute respiratory viral infection on the formation of postvaccinal measles immunity]. / O vliianii ostroí respiratornoí virusnoí infektsii na formirovanie protivokorevogo postvaktsinal'nogo immuniteta.

The formation of postvaccinal measles immunity under the conditions of the uncomplicated development of the postvaccinal process and in cases of concomitant acute respiratory viral infection (ARVI) was studied. The peculiarities of immunological reaction to ARVI in the postvaccinal period in children were characterized by disturbances in measles antibody synthesis and changes in the ratio and content of immunoglobulins. The negative influence of ARVI especially in cases of its appearance at an early period after vaccination, was manifested in decreased antibody production and in the gradual loss of immunity to measles in some children as they grew older.

[Indices of humoral antimeasles postvaccinal immunity]. / Nekotorye pokazateli gumoral'nogo protivokorevogo postvaktsinal'nogo immuniteta

Inoculation to children of live measles L-16 vaccine was found to cause changes in the content of the main serum classes of immunoglobulins, A, M and G, and synthesis of specific antibody of various physico-chemical nature. Between these two values only a relative correlation was observed at 10--14 and 28--32 days after vaccination. Changes in the synthesis of serum immunoglobulins in the majority of the children were not great and statistically insignificant. Only in 2 children with hypergammaglobulinemia inoculation of measles L-16 vaccine induced intensive (statistically significant) increase in serum M and G globulins. The results indicate the necessity of further study of the effects of live measles vaccine on the immunological status of children which could probably reveal the causes of occurrence of unusual postvaccination reactions and complications.