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Anti-HIV activity of novel phosphonate derivatives of AZT, d4T, and ddA.

Pokrovsky, A G; Pronayeva, T R; Fedyuk, N V; Shirokova, E A; Khandazhinskaya, A L; Tarusova, N B; Karpenko, I L; Krayevsky, A A.

Nucleosides Nucleotides Nucleic Acids ; 20(4-7): 767-9, 2001.

Article in English | MEDLINE | ID: mdl-11563112

ABSTRACT

Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was 2',3'-Dideoxy-2',3'-didehydrothymidine 5'-isopropylphosphite and among the AZT phosphonate derivatives highest activity was shown by 2',3'-Dideoxy-3'-azidothymidine 5'-cyclohexylphosphite.

Subject(s)

Anti-HIV Agents/pharmacology , Dideoxynucleosides/pharmacology , Anti-HIV Agents/toxicity , Cell Line , Cell Survival/drug effects , Dideoxyadenosine/analogs & derivatives , Dideoxynucleosides/toxicity , HIV Core Protein p24/analysis , HIV-1/drug effects , HIV-1/physiology , Humans , Immunoenzyme Techniques , Organophosphonates/pharmacology , Organophosphonates/toxicity , Stavudine/analogs & derivatives , Virus Replication/drug effects , Zidovudine/analogs & derivatives

ABSTRACT

Subject(s)

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