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3.
Contrast Media Mol Imaging ; 2019: 6319476, 2019.
Article in English | MEDLINE | ID: mdl-31263384

ABSTRACT

Ultrasound is a noninvasive routine method that allows real-time monitoring of fetal development in utero to determine gestational age and to detect congenital anomalies and multiple pregnancies. To date, the developmental biology of Chinchilla lanigera has not yet been characterized. This species has been found to undergo placentation, long gestation, and fetal dimensions similar to those in humans. The aim of this study was to assess the use of high-frequency ultrasound (HFUS) and clinical ultrasound (US) to predict gestational age in chinchillas and evaluate the possibility of this species as a new animal model for the study of human pregnancy. In this study, 35 pregnant females and a total of 74 embryos and fetuses were monitored. Ultrasound examination was feasible in almost all chinchilla subjects. It was possible to monitor the chinchilla embryo with HFUS from embryonic day (E) 15 to 60 and with US from E15 to E115 due to fetus dimensions. The placenta could be visualized and measured with HFUS from E15, but not with US until E30. From E30, the heartbeat became detectable and it was possible to measure fetal biometrics. In the late stages of pregnancy, stomach, eyes, and lenses became visible. Our study demonstrated the importance of employing both techniques while monitoring embryonic and fetal development to obtain an overall and detailed view of all structures and to recognize any malformation at an early stage. Pregnancy in chinchillas can be confirmed as early as the 15th day postmating, and sonographic changes and gestational age are well correlated. The quantitative measurements of fetal and placental growth performed in this study could be useful in setting up a database for comparison with human fetal ultrasounds. We speculate that, in the future, the chinchilla could be used as an animal model for the study of US in human pregnancy.


Subject(s)
Chinchilla/growth & development , Contrast Media/pharmacology , Fetal Development/physiology , Ultrasonography/methods , Animals , Disease Models, Animal , Female , Gestational Age , Humans , Pregnancy , Ultrasonography, Prenatal/methods
9.
Rev. patol. respir ; 19(1): 20-21, ene.-mar. 2016. ilus
Article in Spanish | IBECS | ID: ibc-150270

ABSTRACT

La trombosis venosa pulmonar es una enfermedad potencialmente mortal. Este síndrome puede simular clínicamente un embolismo pulmonar arterial, pero tiene una estrategia de investigación y pronóstico distinto. La trombosis de la vena pulmonar es difícil de diagnosticar clínicamente y, por lo general, requiere una combinación de métodos diagnósticos utilizados convencionalmente. Presentamos la imagen radiológica de una trombosis venosa pulmonar en un varón de 70 años en el que la sospecha clínica inicial fue de tromboembolismo pulmonar arterial


Pulmonary vein thrombosis (PVT) represents a potentially fatal disease. This syndrome may clinically mimic pulmonary embolism but has a different investigation strategy and prognosis. Pulmonary vein thrombosis is difficult to diagnose clinically and usually requires a combination of conventionally used diagnostic modalities. We present the radiological images of a pulmonary vein thrombosis in a 70 year old patient with the initial clinical suspicion of a pulmonary artery thromboembolism


Subject(s)
Humans , Male , Aged , Venous Thrombosis/mortality , Venous Thrombosis/diagnosis , Venous Thrombosis/pathology , Pulmonary Embolism , Radiography/methods , Radiography , Lung Neoplasms , Men's Health , Aged , Case Reports
11.
Int J Tuberc Lung Dis ; 17(7): 992-4, 2013 Jul.
Article in English | MEDLINE | ID: mdl-23743320

ABSTRACT

Primary pulmonary botryomycosis, or bacterial pseudomycosis, is an unusual bacterial infection characterised by the formation of eosinophilic granules that resemble those of Actinomyces species infection. The diagnosis of botryomycosis is based on culture of the granules revealing gram-positive cocci or gram-negative bacilli. The bacterial pathogen most frequently found is Staphylococcus aureus. The pathobiology remains unknown. Pulmonary botryomycosis can resemble actinomycosis, tuberculosis or invasive carcinoma. Definitive treatment requires a combination of both surgical debridement and long-term antimicrobial therapy. We present a case of primary pulmonary botryomycosis in an immunocompetent patient.


Subject(s)
Bacterial Infections/diagnosis , Lung Diseases/diagnosis , Lung Neoplasms/diagnosis , Aged, 80 and over , Bacterial Infections/microbiology , Eosinophils/metabolism , Humans , Immunocompetence , Lung Diseases/microbiology , Lung Neoplasms/pathology , Male
12.
Pediatr Med Chir ; 21(6): 285-7, 1999.
Article in Italian | MEDLINE | ID: mdl-11293150

ABSTRACT

The use of antiepileptic drugs in pregnancy may be responsible of minor or major developmental abnormalities at birth or in infancy. The severity of effects and heterogeneity of that abnormalities might be related to a special genetic background giving the fetus a predisposition for epilepsy and vulnerability to major or minor anomalies. The authors report the case of a pregnant woman self prescribing of a politherapy without medical control. She gave birth to a newborn with sever intrauterin retardation, various dysmorphic features and moderate psychomotor delayed.


Subject(s)
Abnormalities, Drug-Induced/etiology , Anticonvulsants/adverse effects , Epilepsy/drug therapy , Pregnancy Complications/drug therapy , Female , Humans , Infant, Newborn , Male , Pregnancy
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