ABSTRACT
The content was studied of vasoactive intestinal peptide (VIP), substantia P (SP), bombesine (BMB), prostaglandins (PG) E2, F2alpha, 6-keto-F1alpha, Tx A2, and leukotrien (LT) B4 in the expired air condensate with the aid of the radioimmune technique to reveal a relation between pulmonary tachykinins and eicosanoids in obstructive type respiratory incompetence in patients with pulmonary tuberculosis. In patients with pulmonary tuberculosis, a high level of BMB was measurable in the expired air condensate. A linear negative correlation has been established between BMB content and forced expiratory volume, SP and respiratory volume, SP and lung capacity. In pulmonary tuberculosis, PGE2 and PGF2alpha levels are significantly evaluated. There was a positive correlation between BMB content and PGF2a in the expired air condensate, which fact suggests their synergic action on the smooth muscles of the bronchi and bronchioles.
Subject(s)
Eicosanoids/analysis , Respiratory Insufficiency , Respiratory Mechanics/physiology , Tachykinins/analysis , Tuberculosis, Pulmonary , Breath Tests , Bronchi/metabolism , Eicosanoids/metabolism , Humans , Muscle, Smooth/metabolism , Respiratory Insufficiency/complications , Respiratory Insufficiency/metabolism , Respiratory Insufficiency/physiopathology , Tachykinins/metabolism , Tuberculosis, Pulmonary/complications , Tuberculosis, Pulmonary/metabolism , Tuberculosis, Pulmonary/physiopathologyABSTRACT
Results are submitted of studying the moisture-eliminating function of the lungs in healthy individuals who did not take part in the elimination of the aftermath of Chernobyl breakdown, and those having participated in the above attempts. The moisture-eliminating function of the lungs was found out to be varying and dynamic, being age-associated as well as dependent upon the position of the examinee on the right or left side. There can be noted relatedness of the moisture-eliminating function of the lungs to some ecological factors (moderate doses of ionizing radiation).
