ABSTRACT
Possible age-related changes in the nerve cell population of the inferior olive were studied through densitometric analysis. The mean area per nerve cell, the reciprocal of the number of cells per unit area, was derived from the distance to closest neighbor in an unselected autopsy series of specimens from 26 subjects without signs of neurological damage, aged 24 to 83 years. Kendall's rank method showed correlation between the mean area per nerve cell and the subjects' ages, with mean areal values decreasing with age. The increase in neuronal density with age was related to changes occurring in the neuropil of the adult. These changes consist of regression of olivocerebellar contacts and loss of supernumerary axonal collaterals, with a resulting decrease in the volume of the whole formation. In addition, the data supported the hypothesis that the nerve cell population of the inferior olive should not decrease with aging.
Subject(s)
Aging/physiology , Olivary Nucleus/growth & development , Adult , Aged , Aged, 80 and over , Cell Count , Female , Humans , Male , Middle Aged , Olivary Nucleus/cytologyABSTRACT
An unusual case of atypical carcinoid tumor which arose in chronic ulcerative colitis is presented. The authors describe the argyrophilic cell hyperplasia in damaged colonic areas as a possible reaction to injury and the relationship of the carcinoid tumors to the argyrophilic cell hyperplasia.
Subject(s)
Carcinoid Tumor/complications , Colitis, Ulcerative/complications , Colonic Neoplasms/complications , Carcinoid Tumor/analysis , Carcinoid Tumor/pathology , Colitis, Ulcerative/pathology , Colonic Neoplasms/analysis , Colonic Neoplasms/pathology , Histocytochemistry , Humans , Male , Middle AgedSubject(s)
Calcium Channel Blockers/therapeutic use , Hemodynamics/drug effects , Isometric Contraction/drug effects , Muscle Contraction/drug effects , Myocardial Infarction/drug therapy , Verapamil/therapeutic use , Adult , Calcium Channel Blockers/pharmacology , Cardiac Catheterization , Female , Hand , Humans , Male , Middle Aged , Myocardial Infarction/physiopathology , Verapamil/pharmacologyABSTRACT
The authors report an experiment undertaken with trazodone in the treatment of different forms of pathological involuntary movements. Forty-five subjects were treated for two months; 15 were affected with L-DOPA + decarboxylase inhibitor induced dyskinesias, 9 with choreic or choreoathetosic syndromes, 6 with primary buccolingual dyskinesias, 4 with ticks, 9 with tremors--3 of whom had delirium tremens--and 1 case of Wilson's disease with severe postural dystonia. At the end of treatment there was a considerable improvement in 40 cases (88.9%), 17 of whom (37.8%) had a reduction of over 65% of symptoms. The results were good in all the groups considered; particularly interesting were those obtained in delirium tremens, alcoholic induced tremor, primary buccolingual dyskinesias, L-DOPA + decarboxylase inhibitor induced dyskinesias. Emphasis is placed on the efficacy of the drug in inhibiting postural dystonia in the one case of Wilson's disease. The good tolerance of the drug was confirmed.
Subject(s)
Movement Disorders/drug therapy , Piperazines/therapeutic use , Trazodone/therapeutic use , Adolescent , Adult , Aged , Athetosis/drug therapy , Carboxy-Lyases/antagonists & inhibitors , Child , Chorea/drug therapy , Dyskinesia, Drug-Induced/drug therapy , Female , Humans , Levodopa/antagonists & inhibitors , Male , Middle Aged , Tic Disorders/drug therapy , Trazodone/administration & dosage , Tremor/drug therapyABSTRACT
The Authors consider the pathologic anatomy and histology of cases of death in diving and compare with a standard sample of drowned persons. The findings are not specific but like those of dead of asphyxia. They discuss several causes of death in diving and emphasize weighing of all other data for diagnosis of death and medico-legal problems.
