ABSTRACT
At Montefiore Medical Center, 140 pediatric recipients have received 155 renal allografts over a 16-year period with an overall 6% mortality. Graft survival was not significantly different based upon race or sex of recipient. Graft survival was significantly better for first time transplants and the youngest recipients. Graft survival was significantly improved using Tacrolimus immunosuppression.
Subject(s)
Kidney Transplantation , Academic Medical Centers , Adolescent , Adult , Age Factors , Child , Child, Preschool , Female , Graft Survival , Histocompatibility Testing , Humans , Infant , Kidney Transplantation/immunology , Kidney Transplantation/mortality , Kidney Transplantation/statistics & numerical data , Male , New York City/epidemiology , Racial Groups , Reoperation , Retrospective Studies , Sex Factors , Survival RateABSTRACT
Each year advances are made in the clinical evaluation and treatment of genitourinary tumors in children. Our understanding of cellular, molecular, and genetic processes in tumorigenesis is evolving rapidly. In addition, knowledge concerning long-term outcome and complications associated with current treatments is increasing. In this article, we review recent literature on pediatric rhabdomyosarcoma, Wilms' tumor, and testicular tumors.
Subject(s)
Urogenital Neoplasms , Adrenal Hyperplasia, Congenital/complications , Child , Child, Preschool , Combined Modality Therapy , Cryptorchidism/complications , Humans , Incidence , Infant , Kidney Neoplasms/diagnosis , Kidney Neoplasms/epidemiology , Kidney Neoplasms/genetics , Kidney Neoplasms/pathology , Kidney Neoplasms/therapy , Male , Neoplastic Syndromes, Hereditary/epidemiology , Neoplastic Syndromes, Hereditary/genetics , Oncogenes , Rhabdomyosarcoma/epidemiology , Rhabdomyosarcoma/genetics , Rhabdomyosarcoma/therapy , Testicular Neoplasms/epidemiology , Testicular Neoplasms/etiology , Testicular Neoplasms/genetics , Testicular Neoplasms/therapy , Treatment Outcome , Urogenital Neoplasms/epidemiology , Urogenital Neoplasms/genetics , Urogenital Neoplasms/therapy , Wilms Tumor/diagnosis , Wilms Tumor/epidemiology , Wilms Tumor/genetics , Wilms Tumor/pathology , Wilms Tumor/therapyABSTRACT
Each year advances are made in the clinical evaluation and treatment of genitourinary tumors in children. Our understanding of cellular, molecular, and genetic processes in tumorigenesis is evolving rapidly. In addition, knowledge concerning long-term outcome and complications associated with current treatments is increasing. In this article, we review recent literature on pediatric genitourinary tumors, including Wilms' tumor, rhabdomyosarcoma, and testicular tumors.