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Expression of heparanase-1 in prostate gland tumors.
Kutsenko, O S; Kovner, A V; Mostovich, L A; Kunin, I S; Nepomnyashchikh, R D; Prudnikova, T Yu; Grigor'eva, E V.
Bull Exp Biol Med ; 152(3): 344-7, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22803082

ABSTRACT

Expression of heparanase-1 in prostate tumors was evaluated by RT-PCR, immunoblotting, and immunohistochemistry. Malignant transformation was shown to be associated with considerable increase in the expression of heparanase-1 at both mRNA and protein levels, which correlated with the degree of metastasizing and can be used as the marker for diagnostics of the metastatic process.


Subject(s)
Gene Expression Regulation, Enzymologic/physiology , Gene Expression Regulation, Neoplastic/physiology , Glucuronidase/metabolism , Neoplasm Metastasis/diagnosis , Prostatic Neoplasms/metabolism , DNA Primers/genetics , Humans , Immunoblotting/methods , Immunohistochemistry/methods , Male , Middle Aged , Reverse Transcriptase Polymerase Chain Reaction/methods
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