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Bull Exp Biol Med ; 164(2): 223-228, 2017 Dec.
Article in English | MEDLINE | ID: mdl-29177905

ABSTRACT

We studied the relationship between diffusion transport and morphological and microstructural organization of extracellular matrix of human intervertebral disk. Specimens of the lumbar intervertebral disks without abnormalities were studied ex vivo by diffusion-weighed magnetic resonance imaging, histological and immunohistochemical methods, and electron microscopy. Distribution of the diffusion coefficient in various compartments of the intervertebral disk was studied. Significant correlations between diffusion coefficient and cell density in the nucleus pulposus, posterior aspects of annulus fibrosus, and endplate at the level of the posterior annulus fibrosus were detected for each disk. In disks with nucleus pulposus diffusion coefficient below 15×10-4 mm2/sec, collagens X and XI were detected apart from aggrecan and collagens I and II. The results supplement the concept on the relationship between the microstructure and cell composition of various compartments of the intervertebral disk and parameters of nutrient transport.


Subject(s)
Annulus Fibrosus/metabolism , Nucleus Pulposus/metabolism , Adult , Aggrecans/genetics , Aggrecans/metabolism , Annulus Fibrosus/anatomy & histology , Annulus Fibrosus/diagnostic imaging , Autopsy , Biological Transport , Cell Count , Collagen Type I/genetics , Collagen Type I/metabolism , Collagen Type II/genetics , Collagen Type II/metabolism , Collagen Type X/genetics , Collagen Type X/metabolism , Collagen Type XI/genetics , Collagen Type XI/metabolism , Diffusion , Diffusion Magnetic Resonance Imaging , Female , Gene Expression , Humans , Male , Middle Aged , Nucleus Pulposus/anatomy & histology , Nucleus Pulposus/diagnostic imaging
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