ABSTRACT
The experiments have been performed on 70 male rats weighing 200-250 gr., 53 patients with obliterating atherosclerosis of lower extremities have been examined. Leu-enkephalin analogues (dalargin and DEFN) administration in a dose of 0.1 mg/kg has been determined to decrease cholesterol levels in the blood in acute and chronic experimental hypercholesterolemia. The use of pharmacological preparation -- enkephalin analogue of dalargin in complex treatment of the obliterating atherosclerosis of lower extremities leads to cholesterol concentration decrease, parathormone concentration decrease in the blood of patients and hyperlactatemia decrease in venous blood of the damaged extremity. Leu-enkephalin analogues, action mechanisms and the possibility of their use for atherosclerosis treatment is discussed.
Subject(s)
Arteriosclerosis Obliterans/drug therapy , Enkephalin, Leucine-2-Alanine/analogs & derivatives , Enkephalin, Leucine/analogs & derivatives , Adult , Animals , Arteriosclerosis Obliterans/blood , Cholesterol/blood , Enkephalin, Leucine/therapeutic use , Humans , Lactates/blood , Lipoproteins, HDL/blood , Lipoproteins, LDL/blood , Lipoproteins, VLDL/blood , Male , Middle Aged , Parathyroid Hormone/blood , Rats , Rats, Inbred Strains , Sympatholytics/therapeutic useABSTRACT
It is shown in experiments on mice that injection of Hydra Peptide Morphogen in doses of 30 micrograms/kg normalizes the content of cyclic nucleotides in the liver, disturbed as a result of injury. Hydra Peptide Morphogen did not change the content of cyclic nucleotides in the injured muscle.
Subject(s)
Cyclic AMP/analysis , Cyclic GMP/analysis , Liver/injuries , Muscles/injuries , Neuropeptides/pharmacology , Animals , Female , Liver/metabolism , Male , Mice , Mice, Inbred BALB C , Muscles/metabolism , Neuropeptides/administration & dosage , Pyrrolidonecarboxylic Acid/analogs & derivatives , Time FactorsSubject(s)
Neurosecretory Systems/physiopathology , Stress, Physiological/physiopathology , Animals , Anxiety/physiopathology , Calcium/physiology , Catecholamines/metabolism , Cyclic AMP/metabolism , Endorphins/physiology , Enkephalins/physiology , Enkephalins/therapeutic use , Hypothalamo-Hypophyseal System/physiopathology , Myocardial Infarction/drug therapy , Myocardial Infarction/physiopathology , Myocardium/metabolism , Parathyroid Glands/physiopathology , Pineal Gland/physiopathology , Pituitary-Adrenal System/physiopathology , Rabbits , Rats , Syndrome , Vasopressins/bloodABSTRACT
It has been demonstrated in experiments on rats that acute myocardial ischemia gives rise to a decrease in diuresis, elevation of antidiuretic activity of blood plasma and the blood concentration of immunoreactive aldosterone. Intraperitoneal injection of a synthetic enkephalin analog D-ala2-leu5-arg6-enkephalin in a dose of 1.25 nmol/kg bw resulted in partial normalization of diuresis, reduction in antidiuretic activity of blood plasma and blood aldosterone level to the control values. Naloxone eliminated the effects described. It is concluded that enkephalins have an inhibitory action on aldosterone and vasopressin secretion, with this action being mediated via opiate receptors.
