ABSTRACT
According to the data from the last 4 years, 3.8% of all diagnosed parasitoses are giardiases. During 5 years Giardia intestinalis was found in 24 children hospitalized in the General Hospital of the Wroclaw Voivodship: in 14 girls and 10 boys, 2-12 years old. The parasite was identified coproscopically and on the basis of clinical symptoms. Before the medication, the blood was taken from each child to determine the serotonin level and the (MAO) monoaminooxydaze, enzyme metabolizing serotonin acivity in the blood serum. The results were compared to the values obtained in the control group of 10 healthy children, 3-12 years old. III children were divided into two groups: first consisted of 12 children, 2-5 years old, second--of 12 children, 6-12 years old. In the first group 210% increase of the serotonin level in the blood and slight 32,4% increase of the MAO activity were observed in comparison with the control group. In the second group the serotonin level in the blood increased 221% in comparison with the control, while the MAO actmty increased 45.1%. In older children marced clinical symptoms could be observed, mainly malfunction of the alimentary tract, microelements shortage and anemia. The highest level of serotonin and MAO activity was found in the child with bile duct irritation. The reason for the increased level of serotonin and MAO activity can be pathogenic action of parasite's trophozoites and cysts on the jejunum mucosa and mobilization, proliferation and degranulation of tissue mastocytes. Serotonin, released from mastocytes, can be the cause of enhanced peristalsis and mucosa congestion.
Subject(s)
Giardia lamblia/physiology , Giardiasis/metabolism , Monoamine Oxidase/blood , Serotonin/blood , Animals , Child , Child, Preschool , Feces/parasitology , Female , Giardia lamblia/isolation & purification , Giardiasis/diagnosis , Giardiasis/parasitology , Host-Parasite Interactions/physiology , Humans , Male , Reference Values , Retrospective StudiesABSTRACT
The investigations on the occurrence of CIC were carried out in 65 children with chronic tonsillitis, 39 with hypertrophy of pharyngeal tonsil and 14 children with chronic tonsillitis and hypertrophy of pharyngeal tonsil. Immune complexes were found in 20 children with chronic tonsillitis and in 5 children with chronic tonsillitis and hypertrophy of pharyngeal tonsil. In the control group (20 healthy children) and in children with hypertrophy of pharyngeal tonsil immune complexes are not detected. Screening of CIC in the period from 1 to 3 months after tonsillectomy or adenotonsillectomy showed disappearance of CIC determined by PEG precipitation method.
Subject(s)
Adenoids/immunology , Adenoids/pathology , Antigen-Antibody Complex/blood , Adenoidectomy , Adenoids/surgery , Adolescent , Child , Child, Preschool , Female , Humans , Hypertrophy , Male , Tonsillectomy , Tonsillitis/immunology , Tonsillitis/pathology , Tonsillitis/surgeryABSTRACT
The occurrence of circulating immunological complexes was investigated in 25 children with uveitis (11 with an anterior and 14 with posterior uveitis). The presence of complexes was found in 15 children, among them in 6 with anterior and 9 with posterior uveitis. Besides the diseased children showed a significant lowering of the percentage of the T lymphocytes by simultaneous increased percentage of B lymphocytes and also a raised concentration of the serum immunoglobulins of M, A and G class.
Subject(s)
Antigen-Antibody Complex/analysis , Uveitis/immunology , B-Lymphocytes , Child , Humans , Immunoglobulins/metabolism , Leukocyte Count , T-Lymphocytes , Uveitis/bloodABSTRACT
Children suffering from JCA showed an elevated percentage of OKT4+ T lymphocytes and an increased ratio of OKT4+ to OKT8+ lymphocytes. Several children showing a significant aggravation of the disease, were selected for a 3-week treatment with TFX. In 7 out of 10 patients a pronounced clinical and laboratory improvement was registered, accompanied by a normalization of the OKT4+ to OKT8+ lymphocyte ratio.
Subject(s)
Antigens, Differentiation, T-Lymphocyte/immunology , Arthritis, Juvenile/drug therapy , CD4 Antigens/immunology , Cell Extracts/therapeutic use , T-Lymphocytes/immunology , Thymus Gland/metabolism , Tissue Extracts/therapeutic use , Adolescent , Arthritis, Juvenile/immunology , Child , Female , Humans , MaleABSTRACT
We investigated the frequencies of HLA-A, -B, -C and -DR antigens in diseased and control group with the aim to find immunogenetic factors that influence the pathogenesis and clinical course of juvenile chronic arthritis (JCA). The study was conducted on 73 JCA patients, 24 boys and 49 girls. On the basis of observed HLA antigen frequencies the relative risks (RR) and their statistical significance as well as the attributable risks (delta) were calculated. In the group of 73 JCA children the only statistically significant finding was a decreased RR for DR7. When the calculations were performed on boys taken from the JCA group, significantly higher RR were found for DR5, B27, B40 and A32. Further analysis was performed on clinically defined subgroups of JCA. In 15 children with pauciarticular persistent arthritis significantly increased RR and delta were found for A25, DR2 and DR3. No significant RR were observed in a subgroup of 44 sero-negative polyarticular arthritis. When only boys of this subgroup were selected for calculations, significantly increased frequencies were found for antigens A32, B40, DR1 and DR5. The reason for a stronger association of immunogenetic risk factors in diseased males than females is discussed.
Subject(s)
Arthritis, Juvenile/genetics , HLA Antigens/analysis , Arthritis, Juvenile/immunology , Child , Female , HLA-A Antigens/analysis , HLA-B Antigens/analysis , HLA-C Antigens/analysis , HLA-DR Antigens/analysis , Humans , Male , Phenotype , Risk FactorsABSTRACT
Selected immunologic parameters and effectivity of immunotherapy was evaluated in 117 children (12-month-10-year-1-old) suffering from recurrent respiratory tract infections. All the children displayed a profound depression of T lymphocytes number, which resemble the situation seen in AIDS patients. An increase of serum IgM concentration was also noted. Immunotherapy included treatment with the following preparations: TFX and Levamisol which stimulate T cell functions, Broncho-Vaxom which stimulates specific antibody production and a complex herb preparation PADMA showing undefined general stimulatory activity. Separate group of children was subjected to climatotherapy in Czerniawa Sanatorium and received no immunostimulants. All methods of treatment employed had beneficial effect. The highest percentage of positive results was obtained in children receiving TFX and Levamisol. In all groups under study, an elevation of T cells percentage was observed. This was especially evident in Levamisol treated patients. There was no correlation, however, between T cells number and clinical improvement.
Subject(s)
Bacteria , Cell Extracts , Immunotherapy , Respiratory Tract Infections/therapy , Adjuvants, Immunologic/therapeutic use , Child , Child, Preschool , Climate , Female , Humans , Infant , Leukocyte Count , Levamisole/therapeutic use , Male , Plants, Medicinal , Recurrence , Respiratory Tract Infections/blood , Respiratory Tract Infections/immunology , T-Lymphocytes/immunology , Thymus Extracts/therapeutic useSubject(s)
Psychotropic Drugs/poisoning , Suicide, Attempted/psychology , Adolescent , Child , Female , Humans , Male , PolandABSTRACT
20 children suffering from spastic bronchitis were treated with levamisole, given for 3 consecutive days in two following weeks. Full therapeutic effect was obtained in 16 children and partial effect in 1 child. The clinical improvement was accompanied by an increase of peripheral T lymphocyte number. No significant side effects were observed.
Subject(s)
B-Lymphocytes/immunology , Bronchitis/drug therapy , Hemostasis/drug effects , Levamisole/therapeutic use , T-Lymphocytes/immunology , B-Lymphocytes/drug effects , Child , Child, Preschool , Clinical Trials as Topic , Female , Humans , Immunoglobulins/analysis , Infant , Male , T-Lymphocytes/drug effectsABSTRACT
The investigation on the occurrence of immunological complexes in 20 children with rheumatic fever (RF) and 15 suffering from juvenile rheumatoid arthritis (JRA) were carried out. A group of 15 healthy children served as control. The presence of circulating immune complexes was found in 10 out of 20 children with acute RF and in 12 out of 15 children with JRA. The investigation of immune complexes in the third and sixth week of treatment showed decreasing concentration of proteins determined by PEG precipitation method.
Subject(s)
Antigen-Antibody Complex/analysis , Arthritis, Juvenile/immunology , Rheumatic Fever/immunology , Child , Child, Preschool , Humans , Immunoglobulin A/analysis , Immunoglobulin M/analysis , Prednisone/therapeutic use , Rheumatic Fever/drug therapyABSTRACT
Twenty children with spastic bronchitis were examined to determine T and B lymphocytes, serum immunoglobulins and the presence of antibodies against autologous lymphocytes. T lymphocytes and B lymphocytes with surface IgA were observed to decrease while B lymphocytes with surface IgG increased. Besides, the level of serum A immunoglobulins was elevated but antibodies against autologous lymphocytes were not detected. In 7 severe cases Levamisol was applied. The treatment appeared effective in 6 children. Clinical improvement was accompanied by substantial alterations in the behaviour of the examined elements of the immunological system, i.e. increase of T and B lymphocytes, increased concentration of serum IgM in 5 and IgA in 4 patients.
Subject(s)
Antibody Formation , Bronchial Spasm/immunology , Bronchitis/immunology , Immunity, Cellular , B-Lymphocytes/immunology , Bronchial Spasm/complications , Bronchitis/complications , Child , Child, Preschool , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Infant , Reference Values , T-Lymphocytes/immunologySubject(s)
Abdomen , Pain/psychology , Psychophysiologic Disorders/etiology , Stress, Psychological/complications , Adolescent , Child , Female , Humans , Life Change Events , Male , Pain/etiologyABSTRACT
In a group of 50 children suffering from chronic tonsillitis an increased number of B lymphocytes and decreased number of T lymphocytes was found. The same children after tonsillectomy had almost normal number of T and B lymphocytes.
