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Article in Russian | MEDLINE | ID: mdl-2557859

ABSTRACT

Number of alpha-2-adrenoceptors on the thrombocyte membranes was measured with selective antagonists [H]3 yohimbine in 25 patients with ischemic heart disease (7 patients with unstable 12 with vasospastic and 6 with new onset angina pectoris) and in 16 patients without ischemic heart disease and coronary atherosclerosis (control group). The number of alpha-2-adrenoceptors in patients with unstable angina pectoris (571.0 +/- 92.9) was proved to exceed significantly that in patients with vasospastic (237.9 +/- 30.0) or new onset angina (126.2 +/- 19.3) and in the control group (200.0 +/- 22.5). The number of adrenoceptors tended to decrease during myocardial ischemia.


Subject(s)
Blood Platelets/analysis , Coronary Disease/blood , Receptors, Adrenergic, alpha/analysis , Adolescent , Adult , Angina Pectoris/blood , Angina, Unstable/blood , Female , Humans , Male , Middle Aged , Physical Exertion , Platelet Aggregation/drug effects , Radioligand Assay/methods
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