ABSTRACT
Single injections of Cerebrolysin(R) did not affect the resistance of rats to anoxia, irrespective of age. Cerebrolysin(R) significantly raised the resistance of the young of females injected ten times i.p. with the same dose during pregnancy. The repeated (5-fold) administration of Cerebrolysin(R) significantly raised the resistance of 35-day-old rats to anoxia and, in high concentrations, it also increased the resistance of adult rats. The effect of Cerebrolysin(R) is correlated to the proportion of amino acids, aligopeptides and the nucleotides they contain. The mere administration of a mixture of amino acids or of some other hydrolysate (Testolysin) was ineffective in this respect.
Subject(s)
Amino Acids/therapeutic use , Brain , Hypoxia/prevention & control , Animals , Female , Male , Pregnancy , Rabbits , Rats , Testis , Tissue Extracts/administration & dosage , Tissue Extracts/therapeutic useABSTRACT
In an attempt to discern whether mitochondrial changes during ontogeny are due to increases in number of mitochondria or to increases in number plus changes in their organization, we investigated the enzymatic markers of the inner and outer membranes of mitochondria from cerebral cortex and subcortical material in young and adult rats. We conclude from the data gathered that significant changes do occur in mitochondrial organization, that gradual maturation occurs in the inner membrane during development, especially in the cerebral cortex and considerably less so in the subcortical structures. We found no such changes in the sturucture of the outer membrane during the periods of development examined.
