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Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety.

Marczak, S; Przezdziecka, A; Wicha, J; Steinmeyer, A; Zügel, U.

Bioorg Med Chem Lett ; 11(1): 63-6, 2001 Jan 08.

Article in English | MEDLINE | ID: mdl-11140735

ABSTRACT

1Alpha,25-dihydroxyvitamin D3 diastereomer, differing from the parent compound in configuration at four asymmetric carbon atoms in the rings C/D and side chain (C13, C14, C17 and C20), was synthesized and shown to have a significant affinity for the vitamin D receptor.

Subject(s)

Calcitriol/chemical synthesis , Calcitriol/metabolism , Receptors, Calcitriol/metabolism , Calcitriol/chemistry , Molecular Conformation , Molecular Structure , Protein Binding , Stereoisomerism

ABSTRACT

Subject(s)

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