ABSTRACT
We developed wound coating based on natural biopolymer chitosan with additional components (ceruloplasmin, L-asparaginic acid, and glycerol). Experiments on albino male rats demonstrated its regeneratory, antioxidant, and antibacterial effects on wounds involving all layers of the skin. Due to chemical composition and buffer component, the biodegraded wound coating optimizes all phases of the wound process, accelerates by 22-28% the reparative regeneration, and leads to anatomic and functional restoration of injured sites. High absorption capacity recommends its use in the treatment of wounds with profuse exudation.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Antioxidants/therapeutic use , Chitosan/therapeutic use , Guided Tissue Regeneration/methods , Skin/injuries , Wound Healing/drug effects , Animals , Ceruloplasmin/therapeutic use , Glycerol/therapeutic use , Male , RatsABSTRACT
Instrumental and laboratory monitoring of bone tissue adaptive remodeling processes after total hip replacement conducted for primary osteoarthrosis patients (32 males and 48 females) (coxarthrosis stage III, functional insufficiency stages II and III) with long-lasting joint damage, significant pain syndrome and osteodeficit, indicated osteodeficit intensification compared to the baseline in the implant surrounding areas. These patients showed an increasing cytokine imbalance in the blood serum postsurgically with the primary activation of proinflammatory (osteoresorbing) element and secondary activation of anti-inflammatory element. Structural and functional characteristics of bone tissue in the area adjacent to the implant and cytokine balance indexes in the blood serum did not return to the baseline even 12-15 months postsurgically.
