1.
J Nat Prod
; 62(8): 1163-4, 1999 Aug.
Article
in English
| MEDLINE
| ID: mdl-10479328
ABSTRACT
A new cembranoid diterpene, neocrotocembranal (3), was isolated from the stem bark of Croton oblongifolius. Its structure was established on the basis of spectroscopic analysis. This compound inhibited platelet aggregation induced by thrombin, with an IC50 value of 47.21 microg/mL, and exhibited cytotoxicity against P-388 cells in vitro, with an IC(50) value of 6.48 microg/mL.
Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Diterpenes/isolation & purification , Euphorbiaceae/chemistry , Animals , Antineoplastic Agents, Phytogenic/pharmacology , Diterpenes/pharmacology , Drug Screening Assays, Antitumor , In Vitro Techniques , Leukemia P388/drug therapy , Magnetic Resonance Spectroscopy , Plant Epidermis/chemistry , Plant Stems/chemistry , Platelet Aggregation/drug effects , Rabbits , Spectrophotometry, Ultraviolet
2.
J Nat Prod
; 61(5): 652-4, 1998 May.
Article
in English
| MEDLINE
| ID: mdl-9599269
ABSTRACT
Two new cembranoids, crotocembraneic acid (1) and neocrotocembraneic acid (2), were isolated from the stem bark of Croton oblongifolius. Their structures were established on the basis of spectroscopic analysis.
