1.
Chem Pharm Bull (Tokyo)
; 43(4): 537-46, 1995 Apr.
Article
in English
| MEDLINE
| ID: mdl-7600609
ABSTRACT
Antitumor, antimicrobial, and phytotoxic activities of the marine antibiotic pentabromopseudilin (1a) and related phenyl-, benzyl- and benzoyl pyrroles were compared. All activities depended strongly on the substituent pattern, with the natural compound 1a being the most active one. As judged from model reactions, a covalent bond of nucleophiles to the pyrrole system may be involved in the inhibition of macromolecular syntheses.