Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Antibodies, Monoclonal/therapeutic use , Hepatitis/drug therapy , Methylprednisolone Hemisuccinate/therapeutic use , Still's Disease, Adult-Onset/drug therapy , Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/therapeutic use , Adult , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Female , Humans , Infliximab , Methylprednisolone Hemisuccinate/administration & dosageABSTRACT
The authors report the case of benign fibrous histiocytoma (BFH) of the skull base in an 11-month-old girl. During draining for a middle ear infection, the child was noted to have an anomalous mass in the skull base. On magnetic resonance imaging studies a soft-tissue mass of the skull base primarily involving the regions of the temporal and occipital bones was discovered. Results of a surgical biopsy were consistent with BFH. At the most recent follow-up examination--18 months postoperatively--the child was noted to be asymptomatic with no gross increase in tumor size.
Subject(s)
Histiocytoma, Benign Fibrous/surgery , Skull Base Neoplasms/surgery , Biomarkers, Tumor/analysis , Biopsy , Female , Follow-Up Studies , Histiocytoma, Benign Fibrous/diagnosis , Histiocytoma, Benign Fibrous/pathology , Humans , Infant , Occipital Bone/pathology , Occipital Bone/surgery , Skull Base Neoplasms/diagnosis , Skull Base Neoplasms/pathology , Temporal Bone/pathology , Temporal Bone/surgeryABSTRACT
We retrospectively studied the use of endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) as a tool for the diagnosis of deep-seated lymphoma. An on-site assessment at the time of EUS-FNAB was performed by a cytopathologist using Diff-Quik (American Scientific Products, McGraw Park, IL) stain. In addition, Papanicolaou stains were performed on EUS-FNAB smears, immunohistochemical stains were performed on cell blocks, and additional samples were sent for flow cytometric analysis. Final cytologic diagnosis was correlated with surgical pathology and/or clinical follow-up. We evaluated EUS-FNAB specimens of deep-seated lymph nodes, spleen, stomach, and pancreas, and 1 EUS-guided needle core biopsy specimen of a lymph node. Thirteen cases of deep-seated lymphoma were diagnosed, including non-Hodgkin lymphomas and Hodgkin lymphoma. One case of hairy cell leukemia was diagnosed. EUS-FNAB is a minimally invasive, cost-effective, and useful tool for the primary diagnosis or staging of deep-seated lymphomas.