Structural and histoenzymatic aspects of metronidazol on rat gonads.

Metronidazol, an efficient drug for Trichomonas vaginalis, Lamblia intestinalis and some anaerobic germs, administered in a daily dose of 500 mg/kg body weight for 60 and 40 days in males and females, respectively, produces severe structural alterations (atrophy and cytolysis, more apparent in the testicle) and elicits, a functional impairment as well (modifications in the activity of some enzymes: alkaline and acide-phosphatase, Mg(2+)-ATPase, CyOx, SDH, LDH). These morphological and histoenzymological changes in the steroidogenic formations suggest that Metronidazol severily affects the gametogenesis and hormonogenesis in rat.