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Folia Microbiol (Praha) ; 52(5): 519-24, 2007.
Article in English | MEDLINE | ID: mdl-18298050

ABSTRACT

The vacA and cagA genotypes of Helicobacter pylori exhibited distinct geographic distribution and correlation with severity of disease. In the above genotypes (obtained from 150 H. pylori-positive patients--139 with gastritis, 10 with ulcer and 1 patient with gastric cancer) combinations vacA s1/m1 and s2/m2 were detected using PCR in 75 and 25% of isolates, respectively, in patients with chronic gastritis. The of s1/m1 and s2/m2 combinations were also detected from ulcers (60 and 40%, respectively). The cagA was detected in 30% of isolates. Concentrated culture supernatants of 7 (64%) out of 11 H. pylori strains induced vacuolization in Vero cells in titers ranging from 1:5 to 1:40. The vacA s1 genotype was significantly associated with, but not predictive of the presence of vacuolating cytotoxin activity and the cagA gene.


Subject(s)
Helicobacter Infections/microbiology , Helicobacter pylori/genetics , Stomach Diseases/microbiology , Adult , Aged , Antigens, Bacterial/genetics , Argentina/epidemiology , Bacterial Proteins/genetics , Cytotoxins/biosynthesis , Gastroscopy , Genotype , Helicobacter Infections/epidemiology , Helicobacter pylori/isolation & purification , Humans , Middle Aged , Phenotype , Polymerase Chain Reaction , Stomach Diseases/epidemiology
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