1.
J Chromatogr
; 490(2): 470-3, 1989 May 30.
Article
in English
| MEDLINE
| ID: mdl-2768419
2.
Int J Clin Pharmacol Ther Toxicol
; 23(6): 298-301, 1985 Jun.
Article
in English
| MEDLINE
| ID: mdl-4018929
ABSTRACT
The bioavailability of tranexamic acid after the administration of a single intramuscular dose was estimated in three healthy male volunteers. 500 mg tranexamic acid were given intramuscularly and intravenously, as a bolus injection, to each subject on separate occasions. Following intramuscular administration, the peak plasma concentrations were attained after approximately one hour and the apparent elimination half-life was about two hours. The absolute bioavailability was 105.2 +/- 10.7% (mean +/- SD). At the dose given, the bioavailability of tranexamic acid after intramuscular administration is fast and complete.