[Anxiodepressive and neuromediatory disorders in hypertensive patients. Effects of cypramil therapy].

AIM: To investigate psychic status and characteristics of neuromediatory metabolism in hypertensive patients, efficacy of antihypertensive therapy with lisinopril and hydrochlorthiaside with adjuvant citalopram (cipramil) which is a selective inhibitor of serotonin reuptake. MATERIAL AND METHODS: Fifty patients with hypertension stage II (37 females, 13 males, mean age 48 years, mean duration of the disease 10.6 years) have undergone psychometric examination, estimation of evoked potentials P-300, 24-h monitoring of blood pressure. Plasma levels of epinephrine and norepinephrine, plasma and platelet levels of serotonin and 5-OIAA were measured at high-performance liquid chromatography. RESULTS: Hypertensive patients were found to have high levels of depression, reactive and personality anxiety, subnormal quality of life. Blood pressure lowered more in patients given adjuvant cipramil. CONCLUSION: Hypertensive patients have anxiodepressive disorders accompanied by monoamines disbolism. Cipramil effectively corrects these disorders.

[The effect of steroid hormones and antimigraine preparations on serotonin transport in the thrombocytes of persons suffering from migraine and in healthy subjects]. / Issledovanie vliianiia steroidnykh gormonov i protivomigrenevykh preparatov na transport serotonina v trombotsitakh lits, stradaiushchikh migren'iu, i zdorovykh liudei.

The study tested the hypothesis that there are significant changes in the structure of serotonin transport system as a result of which steroid hormones in physiological concentrations are capable of interacting with this system of the patients. The influence of steroid hormones (estradiol, testosterone, hydrocortisone, corticosterone) as well as of migraine control preparations (nicergoline, methysergide, tolphenamic acid, cinnarizin, flunarizine) on the capture and release of (3H)-serotonin from the thrombocytes of patients with migraine and healthy subjects was compared. The systems mediating the capture and release of (3H)-serotonin from the thrombocytes of patients were found to be highly sensitive to certain steroid hormones and migraine control preparations. The experimental results appear to attest to the presence of structural changes in these systems. At the same time, the sensitivity of thrombocytes to steroid hormones was increased insufficiently for these hormones in physiological concentrations to be able to interact with the systems mediating the capture and release of serotonin from the patients' thrombocytes.

[The effect of antimigraine preparations on serotonin transport in the brain synaptosomes of rats]. / Vliianie protivomigrenevykh preparatov na transport serotonina v sinaptosomakh mozga krys.

Methisergide and nicergoline act as competitive inhibitors whereas tolfenamic acid as a non-competitive inhibitor of 3H-serotonin accumulation which occurs with the involvement of the high-affinity system of serotonin uptake by the rat brain synaptosomes. Methisergide, nicergoline and tolfenamic acid at concentrations ranging close to Ki value were found to enhance the basal and K(+)-induced release of 3H-serotonin from the rat brain synaptosomes. The findings obtained indicate the ability of the drugs to disturb serotonin transport. In addition, the drugs are likely to exert the depleting effect on serotonin stores in serotoninergic neurons. Picamilon failed to affect either the uptake or the release of serotonin from the rat brain synaptosomes.

[Transport of x-ray contrast media in isolated target and nontarget cells]. / Trasport rentgenokontrastnykh sredstv v izolirovannykh kletkakh-misheniakh i kletkakh-nemischeniakh.

It was found that the accumulation of 125I-bilignost by isolated hepatocytes as target cells is mediated by the saturated and unsaturated systems. In thymocytes as non-target cells no saturated system of 125I-bilignost absorption was detected. 125I-triombrast transport in isolated hepatocytes and thymocytes takes place by usual diffusion.

[Dexamethasone and corticosterone binding by glucocorticoid-resistant and glucocorticoid-sensitive thymocytes in vitro and in vivo]. / Sviazyvanie gliukokortikoidochuvstvitel'nymi i gliukokortiko-rezistentnymi timotsitami deksametazona i kortikosterona in vitro i in vivo.

No correlation between the sensitivity of thymocytes to glucocorticoids and the number of glucocorticoid receptors has been revealed in studies carried out in vivo and in vitro. The micromedium of the thymus has been found capable of accumulating glucocorticoid hormones.