[Effect of multiple injections of hepatic chalones on the multiplication of hepatoma 22a cells and the primary immune response in the body]. / Vliianie mnogokratnogo vvedeniia pechenochnykh keilonov na razmnozhenie kletok gepatomy 22a i pervichnyi immunnyi otvet organizma.

The amount of dividing and DNA-synthesizing cells was investigated in 22a hepatoma after injection of hepatic chalones to mice every 6 hours. Chalones were proved to lower sharply these indices, 3-6 h later they reach minimal values and remain at the lower level during the whole period of the investigation (27 h). Despite a pronounced inhibitory effect in the proliferating cell population there is a tendency to rhythmic proliferative processes. After cessation of prolonged (8 days) injections of the preparation the level of cell proliferation restores only by the 48th h after the last injection and the lifetime of animals with the tumour becomes twice as long. The preparation used possesses no immune properties.