ABSTRACT
The aim of this study was to determine the effect of butaphosphan and cyanocobalamin (BTPC) supplementation on plasma metabolites and milk production in postpartum dairy cows. A total of fifty-two Holstein cows were randomly assigned to receive either: (1) 10 ml of saline (NaCl 0.9%, control group); (2) 1000 mg of butaphosphan and 0.5 mg of cyanocobalamin (BTPC1 group); and (3) 2000 mg of butaphosphan and 1.0 mg of cyanocobalamin (BTPC2 group). All cows received injections every 5 days from calving to 20 days in milk (DIM). Blood samples were collected every 15 days from calving until 75 DIM to determine serum concentration of glucose, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BHB), cholesterol, urea, calcium (Ca), phosphorus (P), magnesium (Mg), aminotransferase aspartate (AST) and γ-glutamyltransferase (GGT). The body condition score (BCS) and milk production were evaluated from calving until 90 DIM. Increasing doses of BTPC caused a linear reduction in plasma concentrations of NEFA and cholesterol. Supplementation of BTPC also reduced concentrations of BHB but it did not differ between the two treatment doses. Milk yield and milk protein had a linear increase with increasing doses of BTPC. A quadratic effect was detected for milk fat and total milk solids according to treatment dose, and BTPC1 had the lowest mean values. Concentrations of glucose, urea, P, Mg, AST, GGT, milk lactose and BCS were not affected by treatment. These results indicate that injections of BTPC during the early postpartum period can reduce NEFA and BHB concentrations and increase milk production in Holstein cows.
Subject(s)
Cattle/metabolism , Micronutrients/pharmacology , Milk/drug effects , Milk/metabolism , Organophosphorus Compounds/pharmacology , Postpartum Period/drug effects , Animals , Blood Chemical Analysis/veterinary , Body Composition/drug effects , Brazil , Dietary Supplements/analysis , Dose-Response Relationship, Drug , Drug Combinations , Female , Injections, Intramuscular/veterinary , Lactation , Micronutrients/administration & dosage , Milk/chemistry , Organophosphorus Compounds/administration & dosage , Vitamin B 12/administration & dosage , Vitamin B 12/pharmacologyABSTRACT
Os autores inocularam vinte bezerros, desprovidos de colostro, 24 horas após o nascimento, com uma suspensäo de Escherichia coli. Os animais foram controlados durante dez dias. Cinco dos bezerros foram mantidos como controle, sem medicaçäo. Os demais, logo após o aparecimento de alteraçöes nas fezes, foram tratados com Baytril. Obteve-se a cura da infecçäo em 100% dos animais tratados, enquanto os näo tratados morreram 3 a 5 dias após a inoculaçäo.
