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J Pediatric Infect Dis Soc ; 4(2): e17-21, 2015 Jun.
Article in English | MEDLINE | ID: mdl-26185621

ABSTRACT

N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk of viral reactivation.


Subject(s)
Acyclovir/therapeutic use , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/therapy , Encephalitis, Herpes Simplex/complications , Encephalitis, Herpes Simplex/therapy , Immunosuppression Therapy/methods , Receptors, N-Methyl-D-Aspartate/immunology , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnostic imaging , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/rehabilitation , Antiviral Agents/therapeutic use , Autoantibodies/immunology , Clonidine/therapeutic use , Diazepam/therapeutic use , Encephalitis, Herpes Simplex/diagnostic imaging , Encephalitis, Herpes Simplex/rehabilitation , Encephalomalacia/diagnostic imaging , Encephalomalacia/etiology , Female , Fever/etiology , Humans , Immunocompromised Host/drug effects , Immunocompromised Host/immunology , Infant , Leukoencephalopathies/diagnostic imaging , Leukoencephalopathies/etiology , Movement Disorders/etiology , Neurological Rehabilitation , Pakistan , Paresis/etiology , Phenobarbital/therapeutic use , Phenytoin/therapeutic use , Plasmapheresis , Seizures/etiology , Trihexyphenidyl/therapeutic use , United Kingdom , Valproic Acid/therapeutic use
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