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J Clin Pharmacol ; 55(3): 348-54, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25328082

ABSTRACT

We investigated the effect of concurrent ingestion of Garcinia kola seed on the pharmacokinetics of quinine. In a randomized crossover study, 24 healthy Nigerian volunteers were assigned into 2 groups (A and B; n = 12 per group) on the basis of G. kola dose orally ingested. Each subject received 600 mg quinine sulfate before and after ingesting 12.5 g of G. kola once daily for 7 days (group A) or 12.5 g twice daily for 6 days and once on the seventh day (group B). Blood samples were collected and analyzed for plasma quinine and its metabolite (3-hydroxyquinine) using a validated high performance liquid chromatography method. Concurrent administration of quinine with G. kola reduced quinine tmax by 48% (group A), mean Cmax by 19% and 26% in groups A and B, respectively, and slight reduction in mean AUC0- ∞ of quinine in both groups. 3-hydroxyquinine Cmax also reduced by 29% and 32%; AUC0-∞ by 13% and 9%, respectively. The point estimates of the T/R ratio of the geometric means for all Cmax obtained and only the AUC0-∞ at a higher dose of G. kola were outside the 80%-125% bioequivalence range. In conclusion, an herb-drug interaction was noted with concurrent quinine and G. kola administration.


Subject(s)
Dietary Supplements , Garcinia kola , Quinine/pharmacokinetics , Seeds , Administration, Oral , Adult , Area Under Curve , Biotransformation , Chromatography, High Pressure Liquid , Cross-Over Studies , Dietary Supplements/adverse effects , Drug Interactions , Female , Half-Life , Healthy Volunteers , Humans , Male , Metabolic Clearance Rate , Nigeria , Quinidine/analogs & derivatives , Quinidine/pharmacokinetics , Quinine/administration & dosage , Quinine/adverse effects , Quinine/blood , Therapeutic Equivalency , Young Adult
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