Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Am J Dermatopathol ; 22(1): 17-21, 2000 Feb.
Article in English | MEDLINE | ID: mdl-10698210

ABSTRACT

CD34 antigen is expressed in normal human skin on endothelium, in spindle cells located around adnexal structures, and in a subset of interstitial cells in the reticular dermis. CD34 expression has also been identified in a number of fibrohistiocytic neoplasms, such as dermatofibrosarcoma protuberans and solitary fibrous tumors of soft tissue. CD34 expression has not previously been described in sclerotic, or "plywood" fibromas. Here presented are three lesions from three patients, in which histologic examination revealed a well-circumscribed dermal nodule composed of spindled cells with focal nuclear pseudo-inclusions. There was extensive fibrosis with hypocellular, storiform areas, characteristic of sclerotic fibroma. The spindled cells strongly expressed CD34, but not factor XIIIa or markers of melanocytic, neural, or muscular differentiation. A diagnosis of Cowden syndrome was considered in one of the cases. These cases provide evidence that CD34 expression can occur in sclerotic fibromas, either solitary or associated with Cowden syndrome. When diagnosing a sclerotic fibroma, one should comment in the report regarding the possibility of Cowden syndrome.


Subject(s)
Antigens, CD34/analysis , Fibroma/immunology , Skin Neoplasms/immunology , Adult , Fibroma/diagnosis , Fibroma/pathology , Hamartoma Syndrome, Multiple/diagnosis , Humans , Immunohistochemistry , Male , Middle Aged , Sclerosis , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology
SELECTION OF CITATIONS
SEARCH DETAIL
...