ABSTRACT
Ten Argentine centers participated in this cooperative trial. One hundred and sixteen patients with endoscopically proven duodenal ulcer entered the study and were randomly assigned to receive either Misoprostol 800 micrograms or Cimetidine 1200 mg, q.i.d. per day, during four weeks of treatment. Patients were allowed to take Amphogel tablets for relief of ulcer pain when necessary, and clinical, lab-tests and adverse effects were evaluated weekly. Ninety-nine patients (Misoprostol 54, Cimetidine 45) completed the study and were evaluable. Success/failure criteria were based on endoscopically documented complete healing at the end of treatment period. Healing rate of four week was 85.2 per cent (46/54) for Misoprostol and 75.5 per cent (34/45) for Cimetidine, with no statistically significant difference. It is concluded that Misoprostol and Cimetidine are highly effective and safety in the healing of active duodenal ulcer. Misoprostol is a new therapeutical alternative for the treatment of duodenal ulcer patients.
Subject(s)
Alprostadil/analogs & derivatives , Cimetidine/therapeutic use , Duodenal Ulcer/drug therapy , Adolescent , Adult , Aged , Alprostadil/adverse effects , Alprostadil/therapeutic use , Cimetidine/adverse effects , Clinical Trials as Topic , Double-Blind Method , Duodenal Ulcer/pathology , Duodenoscopy , Humans , Middle Aged , Misoprostol , Multicenter Studies as Topic , Random AllocationABSTRACT
Ten Argentine centers participated in this cooperative trial. One hundred and sixteen patients with endoscopically proven duodenal ulcer entered the study and were randomly assigned to receive either Misoprostol 800 micrograms or Cimetidine 1200 mg, q.i.d. per day, during four weeks of treatment. Patients were allowed to take Amphogel tablets for relief of ulcer pain when necessary, and clinical, lab-tests and adverse effects were evaluated weekly. Ninety-nine patients (Misoprostol 54, Cimetidine 45) completed the study and were evaluable. Success/failure criteria were based on endoscopically documented complete healing at the end of treatment period. Healing rate of four week was 85.2 per cent (46/54) for Misoprostol and 75.5 per cent (34/45) for Cimetidine, with no statistically significant difference. It is concluded that Misoprostol and Cimetidine are highly effective and safety in the healing of active duodenal ulcer. Misoprostol is a new therapeutical alternative for the treatment of duodenal ulcer patients.
ABSTRACT
Nodular focal hyperplasia is a rare hepatic disease that occasionally is found in patients with rheumatoid arthritis, Felty syndrome, the CRST syndrome, and so on. May be confused with cirrhosis; histologic evaluation of liver biopsy material is essential for diagnosis. Certain drugs should be considered as possible ethiologic factors.
Subject(s)
Liver/pathology , Aged , Diagnosis, Differential , Humans , Hyperplasia , Liver Diseases/pathology , MaleABSTRACT
La hiperplasia nodular focal es una enfermedad hepatica que raramente se la observa aunque ocasionalmente se la puede encontrar en pacientes con artritis reumatoidea sindrome de Felty, sindrome CRST y otros.Esta enfermedad puede ser confundida con cirrosis; el estudio histologico del material proveniente de la biopsia hepatica es essencial para un correcto diagnostico.Ciertas drogas podrian ser consideradas como posibles factores etiologicos
Subject(s)
Aged , Humans , Male , Lymph Nodes , Liver DiseasesABSTRACT
Nodular focal hyperplasia is a rare hepatic disease that occasionally is found in patients with rheumatoid arthritis, Felty syndrome, the CRST syndrome, and so on. May be confused with cirrhosis; histologic evaluation of liver biopsy material is essential for diagnosis. Certain drugs should be considered as possible ethiologic factors.
ABSTRACT
La hiperplasia nodular focal es una enfermedad hepatica que raramente se la observa aunque ocasionalmente se la puede encontrar en pacientes con artritis reumatoidea sindrome de Felty, sindrome CRST y otros.Esta enfermedad puede ser confundida con cirrosis; el estudio histologico del material proveniente de la biopsia hepatica es essencial para un correcto diagnostico.Ciertas drogas podrian ser consideradas como posibles factores etiologicos
