ABSTRACT
During the 18th century, debates about what constituted the sublime flourished in Europe, and particularly in Germany. These debates were nourished by two different visions: The Kantian concept supposed that the sublime is supra-sensible and rooted in reason (Logos) rather than in the object, thus provoking a mental state of tension between nature and art; Edmund Burke's concept, on the other hand, conceived of the sublime as a bodily immersive experience, which we here define as "sensitive" sublime. In summary, Burke's view of the sublime is rooted in the senses and not in the power of reason, unlike Kant's. This was to disrupt the mainstream ideas of that time, unconsciously anticipating some of the recent neuroaesthetic acquisitions regarding the central role played by the sensory apparatus in the experience of beauty and of the sublime.
Subject(s)
Brain , Philosophy , Germany , HumansABSTRACT
According to ancient texts on poetics, the concept of representation is deeply bound to that of "mimesis;" this last was intended in two main ways: as "imitation" and as "world construction." In Aristotle's Poetics, mimesis is theorized as the main form of "world simulation," giving rise to the complex universe of fiction. The concept of simulation plays a pivotal role in the neurocognitive theories on the embodied mind: within this frame, embodied simulation is intended as a functional prelinguistic activation of the human sensorimotor mechanism. This happens not only with regard to intercorporeality and intersubjectivity in the real world but also in relation to the process of imagination giving rise to literary imagery and to the reader's reception of the fictional world, since human beings share a common sensorimotor apparatus. Imagination is a central concept in the recent neurocognitive studies since it plays a core role in human life and in artistic production and reception. Imagination has been considered as a complex emergent cognitive faculty deeply intertwined with perception, memory, and consciousness, shaping human life and transforming the limited horizon of our perceptual affective understanding, being, and acting. Although there is an immense bulk of literature on this topic, imagination is still an elusive concept: its definition and understanding change according to different heuristic frames-mainly the philosophical, aesthetic, poetic, and cognitive ones-giving rise to debates about its modalities and effects, particularly in relation to the construction of aesthetic and symbolic constraints. In this paper, we claim that scientific research may take advantage from the literary representation of the imaginative faculties, which occurs in specific tests characterized by dynamic images and motion. In such meta-representation of the imagination, we witness the phenomenological emergence of endogenous dynamic processes involving a cluster of cognitive faculties, activated by triggering the reader's embodied simulation. One of the main German poets, Johann Wolfgang von Goethe, in the second part of his masterwork Faust II, intuitively represents the very process of the imagination and its responding to embodied simulation with regard both to the author's creative act and to its reception by the reader. At the crossway between literary and neurocognitive, this study aims to highlight the advantage offered to future transdisciplinary inquiries by the literary representation showing features and dynamics of the still mysterious phenomenon of the imagination.
ABSTRACT
OBJECTIVE: While it is widely accepted that inhaled glucocorticosteroids represent an effective treatment for allergic rhinitis, little is known on the specific effects of this therapeutic approach in other upper airway disorders of childhood. The aim of the study was to evaluate the improvement of clinical symptoms and changes in local cellular inflammatory reaction induced by budesonide inhalation suspension in children with recurrent nasal infections using budesonide inhalation suspension delivered by Rinowash, a nebulizer designed to treat upper airway structures. METHODS: In a randomized, controlled-open study, 14 children (5.88+/-0.56 years of age) with recurrent upper airway infections and chronic nasal obstruction were enrolled and randomly treated for 7-10 days either with budesonide inhalation suspension (250 microg/bidie) (nine patients) or with saline solution (five patients). Before and after treatment, inflammatory cells in nasal brushing and nasal symptom score were evaluated. RESULTS: Out of the nine patients treated with budesonide, two were excluded from the analysis because of acute respiratory infections requiring systemic antibiotic treatment. A significant decrease in nasal brushing neutrophil percentage was observed after treatment with budesonide (P=0.016) but not after saline solution treatment (P=1.00). No significant changes in nasal brushing mononuclear cell or eosinophil proportions were observed after treatment with budesonide inhalation suspension or saline solution (P=NS, each comparison). Treatment with budesonide, but not with saline solution, was associated with a significant reduction in nasal obstruction (P=0.016). CONCLUSIONS: These preliminary data indicate that short-term treatment with budesonide inhalation suspension, used for an indication out of label, may significantly reduce local neutrophilic inflammation and nasal obstruction in children with recurrent upper airway infections.
