Endorsement of psychotic-like experiences and problematic cannabis use associated with worse executive functioning performance in undergraduates.

BACKGROUND: Emerging adults who endorse more positive psychotic-like experiences (PLEs; bizarre experiences, delusional ideations) may experience greater cannabis-related impairments in executive function. Negative and depressive PLEs are also associated with cannabis use, however, less is known about their relation to executive functioning. Here, we hypothesize that high positive PLEs and cannabis use are associated with worse performance on computerized versions of the Iowa Gambling Task (IGT) and the Card Sorting Task (CST); exploratory analyses are conducted with negative and depressive PLEs. METHODS: We recruited university students (N = 543) who completed an online study consisting of self-report measures of problematic cannabis use (Cannabis Use Disorder Identification Test; CUDIT-R) and PLEs (Community Assessment of Psychotic Experiences; CAPE). Of these, n=270 completed the CST and n=251 completed the IGT. RESULTS: Problematic cannabis use and high endorsement of positive PLEs related to significantly worse performance on the IGT and greater perseverative errors on the CST. In addition, people who endorsed high levels of positive PLEs were also significantly more likely to complete the IGT with less money relative to those who endorsed fewer PLEs, regardless of cannabis use. Further analyses based on negative PLEs revealed a similar pattern for perseverative errors on the CST; depressive PLEs were not related to task performance. CONCLUSION: Findings highlight that problematic cannabis use and more frequent and distressing positive PLEs are associated with poorer executive functioning. Thus, executive functioning may have implications for intervention among those high on both attributes, who are at high risk of onset of psychosis.

The effect of memory load on object reconstruction: Insights from an online mouse-tracking task.

Why can't we remember everything that we experience? Previous work in the domain of object memory has suggested that our ability to resolve interference between relevant and irrelevant object features may limit how much we can remember at any given moment. Here, we developed an online mouse-tracking task to study how memory load influences object reconstruction, testing participants synchronously over virtual conference calls. We first tested up to 18 participants concurrently, replicating memory findings from a condition where participants were tested individually. Next, we examined how memory load influenced mouse trajectories as participants reconstructed target objects. We found interference between the contents of working memory and what was perceived during object reconstruction, an effect that interacted with visual similarity and memory load. Furthermore, we found interference from previously studied but currently irrelevant objects, providing evidence of object-to-location binding errors. At the greatest memory load, participants were nearly three times more likely to move their mouse cursor over previously studied nontarget objects, an effect observed primarily during object reconstruction rather than in the period before the final response. As evidence of the dynamic interplay between working memory and perception, these results show that object reconstruction behavior may be altered by (i) interference between what is represented in mind and what is currently being viewed, and (ii) interference from previously studied but currently irrelevant information. Finally, we discuss how mouse tracking can provide a rich characterization of participant behavior at millisecond temporal resolution, enormously increasing power in cognitive psychology experiments.

Development of RESTORE: an online intervention to improve mental health symptoms associated with COVID-19-related traumatic and extreme stressors.

Background: Frontline healthcare workers, recovered COVID+ patients who had severe illness, and close others of COVID+ patients who have recovered or died are at risk for clinical levels of mental health symptoms in the context of the COVID-19 pandemic. RESTORE (Recovering from Extreme Stressors Through Online Resources and E-health) was specifically designed for this context. RESTORE is a transdiagnostic guided online intervention adapted from evidence-based cognitive-behavioural therapies. Objectives: RESTORE was designed to address depression, anxiety, and posttraumatic stress disorder symptoms associated with exposure to COVID-19-related traumatic and extreme stressors, and to overcome multiple barriers to accessing psychotherapies. Method: This paper describes the intervention components and platform, as well as the principles used to develop RESTORE. Current research and future directions in developing and testing RESTORE are outlined. Results: Preliminary data from an initial uncontrolled trial evaluating RESTORE in frontline healthcare workers is highly promising. Conclusion: We believe RESTORE has great potential to provide accessible, evidence-based psychological intervention to those in great need.

Antecedentes: Los trabajadores de salud de primera línea, los pacientes de COVID positivo recuperados que tenían una enfermedad grave y las personas cercanas a los pacientes de COVID positivo que se han recuperado o fallecido están en riesgo de presentar niveles clínicos de síntomas de salud mental en el contexto de la pandemia de COVID-19. RESTORE (por sus siglas en inglés: Recovering from Extreme Stressors Through Online Resources and E-health: Recuperación de estresores extremos a través de recursos en línea y salud electrónica) fue diseñada específicamente para este contexto. RESTORE es una intervención en línea guiada transdiagnóstica adaptada de terapias cognitivo-conductuales basadas en la evidencia.Objetivos: RESTORE fue diseñado para abordar la depresión, la ansiedad y los síntomas del trastorno de estrés postraumático asociados con la exposición a factores estresantes traumáticos y extremos relacionados con COVID-19, y para superar múltiples barreras para acceder a psicoterapias.Método: Este artículo describe los componentes y la plataforma de la intervención, así como los principios utilizados para desarrollar RESTORE. Se describen las investigaciones actuales y las direcciones futuras para desarrollar y testear RESTORE.Resultados: Los datos preliminares de un ensayo inicial no controlado que evalúa RESTORE en trabajadores de salud de primera línea son muy prometedores.Conclusión: Creemos que RESTORE tiene un gran potencial para brindar una intervención psicológica accesible y basada en la evidencia a quienes más lo necesitan.

An EEG Investigation of the Attention-Related Impact of Mindfulness Training in Youth With ADHD: Outcomes and Methodological Considerations.

OBJECTIVE: The current study examined the impact of an activity-based mindfulness treatment on EEG indices of attention in youth with ADHD aged 11 to 17 years compared with a waitlist control group. METHOD: Pre- and post-treatment, EEG was recorded as participants completed a single-point focus rest task and two active attention tasks. Theta power, beta power, and theta/beta ratio (TBR) were calculated during each task. RESULTS: A significant group by time by task interaction was found that indicated significant improvement in attentional ability, indexed by decreased TBR, for the treatment group but not controls. CONCLUSION: Findings support the benefit of mindfulness treatment for enhancing attentional control in youth with ADHD and extend the literature by providing evidence of these gains at a neural level. Findings also offer methodological support for the use of active attention tasks when examining mindfulness-related attentional gains in youth with ADHD. Directions for future research are discussed.

Age differences in the neural correlates underlying control of emotional memory: An event-related potential study.

The ability to selectively remember important information and forget irrelevant details is fundamental to successful memory. Research has shown that both younger and older adults can intentionally remember and forget information varying in emotional valence; however, whether the neural correlates of these processes change with age is unknown. In this event-related potential (ERP) study, we sought to fill this knowledge gap using the item-directed forgetting (DF) task. Younger and older adults encoded positive, negative, or neutral words that were cued as either to-be-remembered (TBR) or to-be-forgotten (TBF), while brain activity was recorded with electroencephalography (EEG). Behaviorally, both age groups showed DF effects, although the magnitude of DF was reduced in older adults. Moreover, DF was not influenced by the emotional valence of words in either age group. In the brain, age differences emerged across both word- and cue-related ERPs. Whereas the late positive potential (LPP) was greater for negative than positive words in younger adults, older adults showed a reduced LPP for negative versus positive items. In response to memory cues, younger adults' ERPs showed enhanced parietal and frontal positivity following TBR and TBF cues, respectively. In contrast, older adults displayed greater frontal activity while encoding TBR items than younger adults but age invariance in parietal ERPs following TBR cues. Together, these findings suggest that both younger and older adults are able to intentionally forget information that varies in emotional valence but that the neural mechanisms underlying these processes may change with age.

A retroactive spatial cue improved VSTM capacity in mild cognitive impairment and medial temporal lobe amnesia but not in healthy older adults.

Visual short-term memory (VSTM) is a vital cognitive ability, connecting visual input with conscious awareness. VSTM performance declines with mild cognitive impairment (MCI) and medial temporal lobe (MTL) amnesia. Many studies have shown that providing a spatial retrospective cue ("retrocue") improves VSTM capacity estimates for healthy young adults. However, one study has demonstrated that older adults are unable to use a retrocue to inhibit irrelevant items from memory. It is unknown whether patients with MCI and MTL amnesia will be able to use a retrocue to benefit their memory. We administered a retrocue and a baseline (simultaneous cue, "simucue") task to young adults, older adults, MCI patients, and MTL cases. Consistent with previous findings, young adults showed a retrocue benefit, whereas healthy older adults did not. In contrast, both MCI patients and MTL cases showed a retrocue benefit--the use of a retrocue brought patient performance up to the level of age-matched controls. We speculate that the patients were able to use the spatial information from the retrocue to reduce interference and facilitate binding items to their locations.

Neural correlates of cognitive decline in older adults at-risk for developing MCI: evidence from the CDA and P300.

Improving the ability to detect Alzheimer's disease (AD) at the earliest stages is essential to effectively treat afflicted individuals. Electrophysiological signatures are a promising avenue for earlier diagnosis. In the present study, we investigated an ERP component associated with visual working memory capacity, the contralateral delay activity (CDA). Our participants were undiagnosed and supposedly healthy members of the community, but were defined to be at-risk for Mild Cognitive Impairment (MCI) based on performance from a brief, standardized neuropsychological test. We found that older adults at-risk for MCI had a reduced visual working memory capacity and reduced differentiation of the CDA. In a second experiment, we found that the P300, a well-characterized ERP component shown to be useful in determining conversion from MCI to AD, showed reduced amplitude in our at-risk group. Together, these findings suggest that electrophysiological signatures may be especially sensitive markers of the very earliest stages of AD.

In and out of consciousness: sustained electrophysiological activity reflects individual differences in perceptual awareness.

Although significant advances in our understanding of the cognitive and neural processes involved in conscious awareness have occurred in recent years, the precise mechanisms that support consciousness remain elusive. Examining the neural correlates associated with the moment a stimulus enters or exits conscious awareness is one way to potentially identify the neural mechanisms that give rise to consciousness. In the present study, we recorded neural activity using electroencephalography (EEG) while participants observed a bilateral shape-from-motion (SFM) display. While the display is in motion, the observer perceives an object that is immediately segregated from a noisy background. After the motion stops, the observer's experience of the object remains momentarily in awareness, before it eventually fades out of consciousness back into the noisy background. Consistent with subjective reports of perceptual experience, we observed a prominent sustained posterior contralateral negativity known as the contralateral delay activity (CDA). This activity was sustained only in conditions associated with sustained awareness. Interestingly, the amplitude of the CDA was correlated with individual differences in visual awareness, suggesting that this activity plays a significant role in the maintenance of objects in consciousness. The CDA is typically associated with visual short-term memory (VSTM), suggesting that conscious visual awareness may be mediated by the same neural and cognitive mechanisms that support VSTM. Our results demonstrate that the CDA may reflect the contents of conscious awareness, and therefore can provide a measure to track when information moves in and out of consciousness.

Capacity limits during perceptual encoding.

When a unique stimulus is embedded in an otherwise homogenous display, it is thought to "pop-out" due to its relative increase in salience. We investigated whether the visual system has the ability to equally prioritize multiple salient pop-out items competing for awareness or whether this early stage of visual processing is constrained by capacity limits. We used signal detection (d') methods to determine if sensitivity to a salient pop-out item decreases as function of the number of total salient items present in the visual display. Participants engaged in a signal detection task where they had to report the presence or absence of a simple display change that involved either a pop-out or a non-salient distractor stimulus. Results across four experiments consistently showed that sensitivity to changes involving pop-out stimuli was significantly reduced after more than one of these items was present in the visual array. Results are discussed in terms of neural models of visual encoding and other known capacity limits during visual processing.

Multiple attentional control settings influence late attentional selection but do not provide an early attentional filter.

When one is responding to targets containing a specific feature, non-predictive peripheral cues that share this feature lead to faster responses to the target, while cues that do not contain the target feature effectively are ignored, providing evidence for the role of attentional control settings (ACSs) in the contingent capture hypothesis. It is unclear, however, at what stage of processing multiple ACSs are implemented. We took advantage of the excellent temporal resolution of electroencephalography to demonstrate that the maintenance of multiple ACSs influences later stages of attentional selection rather than providing an early attentional filter. N2pc analyses for cues and targets revealed a similar degree of spatial capture for any peripheral cue, regardless of control settings, with target P3s reflecting the application of the ACS color contingencies.

The right time and the left time: Spatial associations of temporal cues affect target detection in right brain-damaged patients.

Humans map timewords such as "yesterday" or "future" onto a mental timeline that holds temporally earlier events on the left side of space and temporally later events on the right side. The perception of time and spatial mapping both are partially subserved by right temporo-parietal brain regions. We tested stroke patients with right-hemisphere lesions on a spatio-temporal cueing task to see whether spatial associations of noninformative temporal cues would elicit the same cognitive deficits as do typical stimulus-driven exogenous cues. While our right brain-damaged patients were able to maintain a mental timeline with words referring to the past sitting to the left and words referring to the future sitting to the right, we also observed that the typical deficit in disengaging from incongruently cued locations persists for noninformative cues that are mapped onto a mental spatial continuum.

Your divided attention, please! The maintenance of multiple attentional control sets over distinct regions in space.

When non-informative peripheral cues precede a target defined by a specific feature, cues that share the critical feature will capture attention while cues that do not will be effectively ignored. We tested whether different attentional control sets can be simultaneously maintained over distinct regions of space. Participants were instructed to respond only to specific colored targets at specific locations. Most trials included non-predictive cues whose location and/or color were either congruent or incongruent with the spatial and/or color properties of the impending target. We observed contingent capture only for cues that were consistent with the attentional control set applied to that region of space. This is the first demonstration that separate attentional control sets can be simultaneously maintained at distinct spatial locations, with implications for the flexibility of endogenous control over automatic attentional orienting.

Visuospatial experience modulates attentional capture: evidence from action video game players.

Visuospatial experience, the prolonged engagement in a demanding visual task, obtained through action video game play enhances several visual and cognitive processes. The underlying mechanisms involved in these processes, however, remain unclear. Here we demonstrate that experience with action video games modulates early sensory processing, resulting in increases sensitivity to salient visual events that capture attention. In two experiments, we show using a Temporal Order Judgment (TOJ) and a Signal Detection Paradigm (d') that action video game players show greater sensitivity to exogenous sensory events in the visual array. These results suggest that visuospatial experience modulates the earliest sensory aspects of visual processing.

Neglected time: impaired temporal perception of multisecond intervals in unilateral neglect.

Recent neuroimaging and neuropsychological studies have suggested that the right hemisphere, particularly frontal regions, is important for the perception of the passage of time. We examined the ability to estimate durations of up to 60 sec in a group of eight patients with unilateral neglect. When estimating multisecond intervals, neglect patients grossly underestimated all durations. On average, healthy controls (HC) demonstrated reasonably accurate estimates of all durations tested. Although the right hemisphere lesioned control patients without neglect also tended to underestimate durations, these underestimations were significantly better than the performance of the neglect group. These findings suggest a pivotal role for a right hemisphere fronto-parietal network in the accurate perception of multisecond durations. Furthermore, these findings add to a growing body of literature suggesting that neglect cannot be understood simply in terms of a bias in orienting attention to one side of space. Additional deficits of the kind demonstrated here are likely to be crucial in determining the nature and extent of the loss of conscious awareness for contralesional events.