[Results of computerized cardio-tomography and radionuclide ventriculography in patients with aortocoronary bypass]. / Ergebnisse der Kardiocomputertomographie und der Radionuklidventrikulographie bei Patienten mit aortokoronarem Bypass.

Cardiocomputer tomography and radionuclide assessment of left ventricular function complete each other in postoperative control of patients with coronary artery bypass grafts. 70 patients with 163 coronary artery bypass grafts had 85% or total bypass graft early postoperative period, 77% after one year and 69% after two years. Sensitivity of cardiocomputer tomography was 75% and accuracy was 84%. The left ventricular functions was unchanged postoperatively.

[Results of the complex evaluation of scintigraphy of the intracardiac space in patients with coronary disease]. / Ergebnisse der komplexen Auswertung der Herzbinnenraumszintigraphie bei Patienten mit koronarer Herzkrankheit.

With the help of the comparison of the results of 95 patients with coronary heart disease who were examined by means of the intracardiac space scintigraphy for the purpose of the subjective subdivision according to the NYHA-classification there is no close correlation between the nuclear-medically obtained functional sizes (EF, maximum ejection and filling rate) and the clinical degree of severity of the disease. Only at the degree of severity 3 and 4 a discrimination is possible. In 64 patients laevocardiographic and coronarographic, respectively, findings were present. The trend to the deterioration of the functional parameters and to the increase of the nuclear-medically recognizable disturbances of the kinetics, respectively, with a more intensive expression of the vascular stenoses is distinctly readable. From the examination in rest in the individual case no statement is possible concerning the findings which are to be expected in the invasive diagnostics. When there are discrepancies between the result of the intracardiac space scintigraphy and the clinical and electrocardiographic preliminary investigations in many cases a clarification becomes possible by the immediately following study under submaximal exercise. On the assumption of a close cooperation with experienced cardiologists the relatively little expensive intracardiac space scintigraphy which does not stress the patient provides an essential evidence for the prognosis and estimation of the functional capacity of the patients with coronary heart disease.

Evaluation of antiarrhythmic activity of prostaglandin F2 alpha in man.

Since prostaglandin (PG) F2 alpha had been shown to act anti-arrhythmically in various animal models and also in preliminary investigations in man, further evaluation of this effect was made in 30 patients with cardiac extrasystoles and in 2 patients with tachycardias. PGF2 alpha was infused intravenously at individually adapted consecutive rates from 5 to 100 micrograms/min each for at least 5 min. In the incidence of extrasystoles a mean maximum decrease of 41% (P less than 0.001) was obtained. One patient showed repeated short interruptions of a ventricular tachycardia. A dose-dependent significant rise in blood pressure and no significant influences on heart rate, PQ interval and QRS interval of the ECG were found. It is concluded that PGF2 alpha has probably no practical importance for the therapy of cardiac arrhythmias.