1.
Planta Med
; 66(5): 473-5, 2000 Jun.
Article
in English
| MEDLINE
| ID: mdl-10909272
ABSTRACT
Bioassay-guided fractionation of the extract from the wood-decayed fungus Xylaria sp. BCC 1067 led to the isolation of five antiplasmodial compounds, (-)-depudecin, (+)-phaseolinone, (+)-phomenone, 19,20-epoxycytochalasin Q, and (E)-methyl 3-(4-methoxyphenoxy)propenoate. These structures were elucidated using spectroscopic methods, especially NMR analysis.
Subject(s)
Antimalarials/isolation & purification , Antineoplastic Agents/isolation & purification , Ascomycota/chemistry , Alkadienes/chemistry , Alkadienes/isolation & purification , Alkadienes/pharmacology , Animals , Antimalarials/chemistry , Antimalarials/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Chromatography, High Pressure Liquid , Epoxy Compounds/chemistry , Epoxy Compounds/isolation & purification , Epoxy Compounds/pharmacology , Fatty Alcohols/chemistry , Fatty Alcohols/isolation & purification , Fatty Alcohols/pharmacology , Humans , Magnetic Resonance Spectroscopy , Naphthols/chemistry , Naphthols/isolation & purification , Naphthols/pharmacology , Plasmodium falciparum/drug effects , Sesquiterpenes/chemistry , Sesquiterpenes/isolation & purification , Sesquiterpenes/pharmacology , Tumor Cells, Cultured
2.
Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.
J Nat Prod
; 62(2): 329-31, 1999 Feb.
Article
in English
| MEDLINE
| ID: mdl-10075777
ABSTRACT
Bioassay-guided fractionation of an extract from the fungus Myrothecium verrucaria BCC 112 resulted in the first isolation of roridin E acetate (5) from nature together with four common macrocyclic trichothecene isomers (1-4). Trichothecenes 1-5, while known as mycotoxins, were evaluated for their high antimalarial activity.
