ABSTRACT
A 4-month-old male infant had a 2-month history of an exfoliative erythroderma and alopecia. Recurrent mucosal infections, diffuse lymphadenopathy, hepatosplenomegaly, lymphocytosis and eosinophilia, anemia, and failure to thrive later developed. Investigation revealed a combined immunodeficiency with T cells of an unusual phenotype in his peripheral blood, skin, and lymph nodes. Our patient's clinical manifestations most closely resemble Omenn's syndrome, a rare form of autosomal recessive combined immunodeficiency.
Subject(s)
Dermatitis, Exfoliative , Failure to Thrive , Immunologic Deficiency Syndromes , Alopecia/pathology , Dermatitis, Exfoliative/pathology , Diagnosis, Differential , Humans , Immunologic Deficiency Syndromes/pathology , Infant , Male , Syndrome , T-Lymphocytes/pathologyABSTRACT
Exogenous localized ochronosis can result from the repeated use of hydroquinone-containing creams, many of which are available over the counter. We report a case that was managed by dermabrasion and CO2 laser. The incidence and proposed etiologies of hydroquinone-induced exogenous ochronosis are reviewed.
Subject(s)
Dermabrasion/methods , Hydroquinones/adverse effects , Laser Therapy/methods , Ochronosis/chemically induced , Ochronosis/surgery , Female , Humans , Middle AgedSubject(s)
Hand Dermatoses , Onychomycosis , Adult , Hand Dermatoses/pathology , Humans , Male , Onychomycosis/pathology , TrichophytonABSTRACT
Numerous disorders affect both the skin and the heart. These include inherited and metabolic disorders, rheumatologic diseases, infectious diseases, and a variety of others. In many instances, awareness of this association allows the dermatologist to assist in identifying potentially life-threatening cardiac conditions.
Subject(s)
Heart Diseases/etiology , Skin Diseases/etiology , Communicable Diseases/complications , Genetic Diseases, Inborn/complications , Humans , Metabolic Diseases/complications , Rheumatic Diseases/complicationsABSTRACT
Chronic sun exposure has been linked to induction of skin cancers including melanoma and aging changes of the skin, has an adverse effect on certain diseases such as lupus erythematosus and is responsible for drug-induced phototoxic reactions. A majority of an individual's lifetime sun exposure may occur during childhood, and thus early photoprotection is desirable. We conducted a written survey of Florida pediatricians regarding their inclusion of sun protection information as part of routine well-child care. The results indicated that a majority of the pediatricians have awareness of the need for parent and patient education about sun-related issues, and most (65%) requested further information and educational materials. This study suggests that expanded educational efforts concerning sun-related health hazards and sun protection would be desirable for physicians involved in pediatric care, for parents, and for children.
