Subject(s)
Blood Pressure Determination/veterinary , Mice , Polarography/methods , Rats , Animals , Animals, NewbornSubject(s)
Cerebrovascular Circulation , Infant, Premature , Humans , Infant, Newborn , Plethysmography/methodsSubject(s)
Brain/blood supply , Arteriovenous Anastomosis/anatomy & histology , Brain/embryology , Brain/growth & development , Capillaries , Cerebral Arteries/anatomy & histology , Child, Preschool , Humans , Infant , Infant, Newborn , Infant, Premature , Pia Mater/blood supply , Veins/anatomy & histologyABSTRACT
Local cerebral blood flow (1CBF) measured by hydrogen saturation technique, and cerebral blood volume (CBV) observed by photoplethysmographic method were investigated in unanesthetized newborn rats. 1CBF in newborn animals was found to be much lower than in the adult ones. In contrast to adult animals, CO2 inhalation in newborn rats failed to increase 1CBF. CBV also remained constant during the CO2 inhalation.
Subject(s)
Animals, Newborn/physiology , Carbon Dioxide/blood , Cerebrovascular Circulation , Hypercapnia/physiopathology , Animals , Blood Flow Velocity , Blood Volume , Oxygen Consumption , Rats , RespirationABSTRACT
It was shown by the plethysmographic method that, in contrast to adult animals, in the newborn rats the blood vessels of the cerebral hemispheres and of diencephalon while displaying a distinct response to oxygen, failed to react to carbon dioxide, the latter being attributed to the low carbonic anhydrase activity in the tissues of these portions of the brain.