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2.
Obes Surg ; 31(5): 1986-1993, 2021 May.
Article in English | MEDLINE | ID: mdl-33423181

ABSTRACT

BACKGROUND: Obstructive sleep apnea (OSA) is an increasingly common disorder associated with increased cardiovascular disease, mortality, reduced productivity, and an increased risk of road traffic accidents. A significant proportion of patients with OSA in the UK are undiagnosed. This study aims to identify risk factors for OSA in an obese cohort. METHOD: A population-based study was conducted of obese patients (BMI ≥ 30 kg/m2) from the Clinical Practice Research Datalink (CPRD). A logistic regression model was used to calculate odds ratios (ORs) for developing OSA according to other clinicopathological characteristics. Multivariate analysis was conducted of individual factors that affect the propensity to develop OSA. Statistical significance was defined as p < 0.050. RESULTS: From 276,600 obese patients identified during a data extraction of the CPRD in July 2017, the prevalence of OSA was 5.4%. The following risk factors were found to be independently associated with increased likelihood of OSA: male sex (OR = 3.273; p < 0.001), BMI class II (OR = 1.640; p < 0.001), BMI class III (OR = 3.768; p < 0.001), smoking (OR = 1.179; p < 0.001), COPD (OR = 1.722; p < 0.001), GERD (OR = 1.557; p < 0.001), hypothyroidism (OR = 1.311; p < 0.001), acromegaly (OR = 3.543; p < 0.001), and benzodiazepine use (OR = 1.492; p < 0.001). Bariatric surgery was associated with reduced risk of OSA amongst this obese population (OR = 0.260; p < 0.001). CONCLUSIONS: In obese patients, there are numerous comorbidities that are associated with increased likelihood of OSA. These factors can help prompt clinicians to identify undiagnosed OSA. Bariatric surgery appears to be protective against developing OSA.


Subject(s)
Obesity, Morbid , Sleep Apnea, Obstructive , Body Mass Index , Humans , Male , Obesity/complications , Obesity/epidemiology , Obesity, Morbid/surgery , Polysomnography , Sleep Apnea, Obstructive/complications , Sleep Apnea, Obstructive/epidemiology , United Kingdom/epidemiology
3.
Diabet Med ; 36(4): 414-423, 2019 04.
Article in English | MEDLINE | ID: mdl-30575115

ABSTRACT

In recent years, bariatric surgery, also referred to as metabolic surgery, has become the most successful treatment option in those with Type 2 diabetes and obesity. There are some similarities in the pathological pathways in Type 1 and Type 2 diabetes, but the use of surgery in Type 1 diabetes remains unestablished and controversial. The treatment and management of Type 1 diabetes can be very challenging but recent advances in surgical interventions and technology has the potential to expand and optimize treatment options. This review discusses the current status of some surgical options available to people with Type 1 diabetes. These include implantable continuous glucose monitoring systems, continuous intraperitoneal insulin infusion pumps, closed-loop insulin delivery systems (also known as the artificial pancreas system) utilizing the latter two modalities of glucose monitoring and insulin delivery, and bariatric or metabolic surgery. Whole pancreas and islet transplantation are beyond the scope of this review but are briefly discussed.


Subject(s)
Bariatric Surgery/methods , Blood Glucose/metabolism , Diabetes Mellitus, Type 1/surgery , Blood Glucose Self-Monitoring , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 1/drug therapy , Drug Implants , Humans , Hypoglycemic Agents/administration & dosage , Insulin/administration & dosage , Insulin Infusion Systems , Islets of Langerhans Transplantation , Pancreas, Artificial
4.
Br J Surg ; 105(12): 1650-1657, 2018 11.
Article in English | MEDLINE | ID: mdl-30003539

ABSTRACT

BACKGROUND: Obesity increases the risk of several types of cancer. Whether bariatric surgery influences the risk of obesity-related cancer is not clear. This study aimed to uncover the risk of hormone-related (breast, endometrial and prostate), colorectal and oesophageal cancers following obesity surgery. METHODS: This national population-based cohort study used data from the Hospital Episode Statistics database in England collected between 1997 and 2012. Propensity matching on sex, age, co-morbidity and duration of follow-up was used to compare cancer risk among obese individuals undergoing bariatric surgery (gastric bypass, gastric banding or sleeve gastrectomy) and obese individuals not undergoing such surgery. Conditional logistic regression provided odds ratios (ORs) with 95 per cent confidence intervals. RESULTS: In the study period, from a cohort of 716 960 patients diagnosed with obesity, 8794 patients who underwent bariatric surgery were matched exactly with 8794 obese patients who did not have surgery. Compared with the no-surgery group, patients who had bariatric surgery exhibited a decreased risk of hormone-related cancers (OR 0·23, 95 per cent c.i. 0·18 to 0·30). This decrease was consistent for breast (OR 0·25, 0·19 to 0·33), endometrium (OR 0·21, 0·13 to 0·35) and prostate (OR 0·37, 0·17 to 0·76) cancer. Gastric bypass resulted in the largest risk reduction for hormone-related cancers (OR 0·16, 0·11 to 0·24). Gastric bypass, but not gastric banding or sleeve gastrectomy, was associated with an increased risk of colorectal cancer (OR 2·63, 1·17 to 5·95). Longer follow-up after bariatric surgery strengthened these diverging associations. CONCLUSION: Bariatric surgery is associated with decreased risk of hormone-related cancers, whereas gastric bypass might increase the risk of colorectal cancer.


Subject(s)
Bariatric Surgery/statistics & numerical data , Neoplasms/etiology , Obesity/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Bariatric Surgery/mortality , Breast Neoplasms/etiology , Breast Neoplasms/mortality , Breast Neoplasms/prevention & control , Colorectal Neoplasms/etiology , Colorectal Neoplasms/mortality , Colorectal Neoplasms/prevention & control , Endometrial Neoplasms/etiology , Endometrial Neoplasms/mortality , Endometrial Neoplasms/prevention & control , Esophageal Neoplasms/etiology , Esophageal Neoplasms/mortality , Esophageal Neoplasms/prevention & control , Female , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Neoplasms/mortality , Neoplasms/prevention & control , Neoplasms, Hormone-Dependent/etiology , Neoplasms, Hormone-Dependent/mortality , Neoplasms, Hormone-Dependent/prevention & control , Obesity/complications , Obesity/mortality , Postoperative Complications/etiology , Postoperative Complications/mortality , Postoperative Complications/prevention & control , Propensity Score , Prostatic Neoplasms/etiology , Prostatic Neoplasms/mortality , Prostatic Neoplasms/prevention & control , Risk Factors , Young Adult
5.
World J Surg ; 42(12): 3874-3879, 2018 12.
Article in English | MEDLINE | ID: mdl-29947990

ABSTRACT

AIMS: Post-operative urinary retention (POUR) is a common cause of unplanned admission following day-case surgery and has negative effects on both patient and surgical institution. We aimed to prospectively evaluate potential risk factors for the development of POUR following day-case general surgical procedures. METHODS: Over a 24-week period, consecutive adult patients undergoing elective day-case general surgery at a single institution were prospectively recruited. Data regarding urinary symptoms, comorbidities, drug history, surgery and perioperative anaesthetic drug use were collected. The primary outcome was the incidence of POUR, defined as an impairment of bladder voiding requiring either urethral catheterisation, unplanned overnight admission or both. Potential risk factors for the development of POUR were analysed by logistic regression. RESULTS: A total of 458 patients met the inclusion criteria during the study period, and data were collected on 382 (83%) patients (74.3% male). Sixteen patients (4.2%) experienced POUR. Unadjusted analysis demonstrated three significant risk factors for the development of POUR: age ≥ 56 years (OR 7.77 [2.18-27.78], p = 0.002), laparoscopic surgery (OR 3.37 [1.03-12.10], p = 0.044) and glycopyrrolate administration (OR 5.56 [2.00-15.46], p = 0.001). Male sex and lower urinary tract symptoms were not significant factors. Multivariate analysis combining type of surgery, age and glycopyrrolate use revealed that only age ≥ 56 years (OR 8.14 [2.18-30.32], p = 0.0018) and glycopyrrolate administration (OR 3.48 [1.08-11.24], p = 0.0370) were independently associated with POUR. CONCLUSIONS: Patients aged at least 56 years and/or requiring glycopyrrolate-often administered during laparoscopic procedures-are at increased risk of POUR following ambulatory general surgery.


Subject(s)
Ambulatory Surgical Procedures/adverse effects , Laparoscopy/adverse effects , Urinary Retention/epidemiology , Age Factors , Elective Surgical Procedures/adverse effects , Factor Analysis, Statistical , Female , Glycopyrrolate/administration & dosage , Humans , Incidence , Male , Middle Aged , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Prospective Studies , Risk Factors , Urinary Retention/etiology
6.
Br J Surg ; 105(3): 287-294, 2018 02.
Article in English | MEDLINE | ID: mdl-29193008

ABSTRACT

BACKGROUND: Eye tracking presents a novel tool that could be used to profile skill levels in surgery objectively. The primary aim of this study was to identify differences in gaze behaviour between expert and junior surgeons performing a laparoscopic Roux-en-Y gastric bypass (LRYGB) for obesity. METHODS: This prospective observational study used a lightweight eye-tracking apparatus to determine the difference in gaze behaviours between expert (more than 75 procedures) and junior (75 or fewer procedures) surgeons at defined stages of LRYGB. Primary endpoints were normalized dwell time and fixation frequency. Secondary endpoints were blink rate, maximum pupil size and rate of pupil change. RESULTS: A total of 20 procedures (12 junior, 8 expert) were analysed. Compared with juniors, experts showed a prolonged dwell time on the screen during angle of His dissection (median (range) 91·20 (83·40-94·40) versus 68·95 (59·80-87·60) per cent; P = 0·001), formation of the retrogastric tunnel (91·50 (85·80-95·50) versus 73·60 (34·60-90·50) per cent; P = 0·001) and gastric pouch formation (86·95 (83·60-90·20) versus 67·60 (37·10-80·00) per cent P < 0·001). Juniors had a greater blink frequency throughout all recorded segments (P < 0·010) and had a larger maximum pupil size during all recorded operative segments (P < 0·010). Rate of pupil change was greater in juniors in all analysed segments (P < 0·010). CONCLUSION: These results suggest that experts display more focused attention on significant stimuli, alongside experiencing a reduced mental workload and having increased concentration. This has the potential for future use in validation of surgical skill in high-stakes assessment.


Subject(s)
Clinical Competence , Fixation, Ocular , Gastric Bypass , Laparoscopy , Obesity, Morbid/surgery , Surgeons/psychology , Female , Gastric Bypass/methods , Humans , London , Male , Prospective Studies , Surgeons/education
7.
Yearb Med Inform ; 10(1): 68-74, 2015 Aug 13.
Article in English | MEDLINE | ID: mdl-26123908

ABSTRACT

OBJECTIVE: To share how an effectual merging of local and online networks in low resource regions can supplement and strengthen the local practice of patient centered care through the use of an online digital infrastructure powered by all stakeholders in healthcare. User Driven Health Care offers the dynamic integration of patient values and evidence based solutions for improved medical communication in medical care. INTRODUCTION: This paper conceptualizes patient care-coordination through the lens of engaged stakeholders using digital infrastructures tools to integrate information technology. We distinguish this lens from the prevalent conceptualization of dyadic ties between clinician-patient, patient-nurse, clinician-nurse, and offer the holistic integration of all stakeholder inputs, in the clinic and augmented by online communication in a multi-national setting. METHODS: We analyze an instance of the user-driven health care (UDHC), a network of providers, patients, students and researchers working together to help manage patient care. The network currently focuses on patients from LMICs, but the provider network is global in reach. We describe UDHC and its opportunities and challenges in care-coordination to reduce costs, bring equity, and improve care quality and share evidence. CONCLUSION: UDHC has resulted in coordinated global based local care, affecting multiple facets of medical practice. Shared information resources between providers with disparate knowledge, results in better understanding by patients, unique and challenging cases for students, innovative community based research and discovery learning for all.


Subject(s)
Patient Care Team/organization & administration , Patient-Centered Care/organization & administration , Professional-Patient Relations , Electronic Health Records , Humans , India , Medical Informatics , Research Personnel
8.
Int J Obes (Lond) ; 39(11): 1565-74, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26081915

ABSTRACT

BACKGROUND: Bariatric surgery is currently the most efficacious treatment for obesity and its associated metabolic co-morbidities, such as diabetes. The metabolic improvements occur through both weight-dependent and weight-independent mechanisms. Bile acids (BAs) have emerged as key signalling molecules that have a central role in modulating many of the physiological effects seen after bariatric surgery. This systematic review assesses the evidence from both human and animal studies for the role of BAs in reducing the metabolic complications of obesity following bariatric surgery. METHODS: We conducted a systematic search of Medline and Embase databases to identify all articles investigating the role of BAs in mediating the metabolic changes observed following bariatric surgery in both animal and human studies. Boolean logic was used with relevant search terms, including the following MeSH terms: 'bile acids and salts', 'bariatric surgery', 'metabolic surgery', 'gastrointestinal tract/surgery' and 'obesity/surgery'. RESULTS: Following database searches (n=1197), inclusion from bibliography searches (n=2) and de-duplication (n=197), 1002 search results were returned. Of these, 132 articles were selected for full-text review, of which 38 articles were deemed relevant and included in the review. The findings support the effects of BAs on satiety, lipid and cholesterol metabolism, incretins and glucose homoeostasis, energy metabolism, gut microbiota and endoplasmic reticulum stress following bariatric surgery. Many of these metabolic effects are modulated through the BA receptors FXR and TGR5. We also explore a possible link between BAs and carcinogenesis following bariatric surgery. CONCLUSIONS: Overall there is good evidence to support the role of BAs in the metabolic effects of bariatric surgery through the above mechanisms. BAs could serve as a novel therapeutic pharmacological target for the treatment of obesity and its associated co-morbidities.


Subject(s)
Bariatric Surgery , Bile Acids and Salts/metabolism , Metabolic Diseases/etiology , Obesity, Morbid/complications , Weight Loss , Endoplasmic Reticulum/metabolism , Energy Metabolism , Gastrointestinal Microbiome , Glucose/metabolism , Homeostasis , Humans , Incretins/metabolism , Lipid Metabolism , Metabolic Diseases/prevention & control , Metabolic Diseases/surgery , Obesity, Morbid/metabolism , Obesity, Morbid/surgery , Receptors, Cytoplasmic and Nuclear/metabolism , Receptors, G-Protein-Coupled/metabolism , Treatment Outcome
9.
Langenbecks Arch Surg ; 400(2): 267-71, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25053508

ABSTRACT

PURPOSE: Traditional management of a perianal abscess involves incision and drainage followed by packing of the cavity until healing by secondary intention is complete. The evidence supporting this is lacking however, and regular postoperative packing is time-consuming, painful and costly. This pilot study aimed to assess whether healing could be achieved safely without packing and to obtain preliminary results to enable sample size calculation in order to facilitate the implementation of a large multicentre randomised controlled trial. ClinicalTrials.gov Identifier: NCT01853267. METHODS: Fourteen patients with perianal abscesses were randomised to packing or non-packing of the abscess cavity postoperatively. Outcome measures were time to healing, abscess recurrence, fistula formation and postoperative pain. RESULTS: Healing in the non-packing group was faster compared to the packing group: mean 26.8 days (95 % confidence interval 22.7 to 30.7) vs 19.5 days (13.6 to 25.4); P = 0.047. There were no differences in recurrence rates between the groups (37.5 % packing group vs 33.3 % non-packing group; P = 0.580) at a median follow-up of 90.0 weeks (interquartile range (IQR) 26.0). In patients presenting with recurrence, one fistula was found in the packing group with no fistulas in the non-packing group. The non-packing group reported less pain 2 weeks postoperatively: median (IQR) 2.00 (3.00) vs 0.00 (1.00); (P = 0.030). CONCLUSION: Within the limitations of a small sample population, the results of this pilot study suggest that not packing the perianal abscess cavity after incision and drainage is safe. Our results show not packing confers less pain with a faster healing time compared with the conventional packing method, and this is a novel finding. These results need to be corroborated in the setting of a larger multicentre randomised controlled trial.


Subject(s)
Abscess/surgery , Anus Diseases/surgery , Bandages , Drainage/methods , Abscess/diagnosis , Adult , Animals , Anus Diseases/diagnosis , Female , Follow-Up Studies , Humans , Male , Middle Aged , Pilot Projects , Postoperative Care/methods , Risk Assessment , Severity of Illness Index , Treatment Outcome
10.
Br J Surg ; 99(3): 324-35, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22101509

ABSTRACT

BACKGROUND: The demand for the highest-quality patient care coupled with pressure on funding has led to the increasing use of quality improvement (QI) methodologies from the manufacturing industry. The aim of this systematic review was to identify and evaluate the application and effectiveness of these QI methodologies to the field of surgery. METHODS: MEDLINE, the Cochrane Database, Allied and Complementary Medicine Database, British Nursing Index, Cumulative Index to Nursing and Allied Health Literature, Embase, Health Business(™) Elite, the Health Management Information Consortium and PsycINFO(®) were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Empirical studies were included that implemented a described QI methodology to surgical care and analysed a named outcome statistically. RESULTS: Some 34 of 1595 articles identified met the inclusion criteria after consensus from two independent investigators. Nine studies described continuous quality improvement (CQI), five Six Sigma, five total quality management (TQM), five plan-do-study-act (PDSA) or plan-do-check-act (PDCA) cycles, five statistical process control (SPC) or statistical quality control (SQC), four Lean and one Lean Six Sigma; 20 of the studies were undertaken in the USA. The most common aims were to reduce complications or improve outcomes (11), to reduce infection (7), and to reduce theatre delays (7). There was one randomized controlled trial. CONCLUSION: QI methodologies from industry can have significant effects on improving surgical care, from reducing infection rates to increasing operating room efficiency. The evidence is generally of suboptimal quality, and rigorous randomized multicentre studies are needed to bring evidence-based management into the same league as evidence-based medicine.


Subject(s)
Quality Improvement/organization & administration , Quality of Health Care/organization & administration , Surgical Procedures, Operative/standards , Anti-Bacterial Agents/therapeutic use , Costs and Cost Analysis , Humans , Infection Control/standards , Length of Stay , Pain, Postoperative/prevention & control , Postoperative Complications/prevention & control , Quality Control , Quality of Health Care/standards , Selection Bias , Waiting Lists
11.
J Robot Surg ; 6(2): 99-114, 2012 Jun.
Article in English | MEDLINE | ID: mdl-27628273

ABSTRACT

The feasibility of robotic surgery has been extensively explored over the past decade with a more recent shift towards defining focused clinical applications for which quantifiable patient benefits can be directly attributed to its use. The aim of this article is to review the current literature on the use of daVinci robotic surgery for the management of rectal cancer and identify the potential benefits, if any, that robotic-assisted total mesorectal excision (RTME) may provide over the current conventional approach. A comprehensive search strategy was used to identify relevant evidence in order to explore the oncological, operative and functional outcome measures for the RTME in addition to quantifying the level of evidence which describes the clinical effectiveness of the daVinci robot in oncological surgery. Both robotic assisted techniques and the primary outcomes are discussed. In total, 23 studies were reviewed across 11 institutions, including one pilot randomised control trial. When data repetition is disregarded, a total of 452 robotic assisted laparoscopic anterior resections and 60 robotic-assisted laparoscopic abdomino-perineal excision of the rectum have been published since the introduction of the daVinci into clinical practice. Feasibility of the daVinci robotic assisted total mesorectal excision is demonstrated, with comparable oncological outcomes presented for rectal cancer excision. A demonstration of a reduced open conversion rate as well as of reduced hospital stay with the use of the robot is highlighted, although further trials are required to confirm both these findings. No functional benefit in using the daVinci could be confirmed due to the lack of focused trials in this area.

12.
Dentomaxillofac Radiol ; 41(1): 70-4, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22184628

ABSTRACT

OBJECTIVES: The aim of this study was to investigate the possibility of reducing patient X-ray dose in the course of implant site evaluation. METHODS: Retrospective practice-based study using a Morita F170 Accuitomo cone beam CT (CBCT) scanner with variable exposure parameters and operating a small cylindrical field of view of 4 cm diameter and 4 cm height. 6 experienced dental surgeons scored the image quality of dental scans on a 5-point scale for adequacy in providing the required information in 2 categories: bone height from alveolar crest to the relevant anatomical structure and bone width. RESULTS: Lower-dose protocols only marginally affected the preference of the reviewers of the resulting images. CONCLUSIONS: There is potential to reduce patient dose very significantly in CBCT examinations for implant site evaluation.


Subject(s)
Alveolar Process/diagnostic imaging , Cone-Beam Computed Tomography/methods , Dental Implantation, Endosseous , Patient Care Planning , Radiation Dosage , Adult , Cephalometry/methods , Cone-Beam Computed Tomography/standards , Dental Implants , Female , Humans , Image Processing, Computer-Assisted/methods , Imaging, Three-Dimensional/methods , Male , Mandible/diagnostic imaging , Maxilla/diagnostic imaging , Maxillary Sinus/diagnostic imaging , Nasal Cavity/diagnostic imaging , Preoperative Care , Radiographic Image Enhancement/methods , Retrospective Studies
13.
Dis Esophagus ; 24(4): 240-50, 2011 May.
Article in English | MEDLINE | ID: mdl-21073622

ABSTRACT

The introduction of surgical robotics to the field of surgical oncology brings with it an expectation not only of improved vision, instrumentation, and precision but also as a result, a potential for improved oncological outcomes. The current interest in the field of oesophagogastric oncology is explored in this review together with the benefits, real and potential, that robotic assistance offers surgical cancer resection as well as some of the limiting factors which may be hampering its uptake into current surgical practice. A systematic review of all the published literature up until April 2010 was examined across the field of esophageal and gastric cancer resection. A quantitative assessment of the oncological, operative, and functional outcomes was determined from each procedure. The level of evidence behind the results was determined using the Oxford Centre for Evidence-based Medicine Levels of Evidence; Therapy and Prevention. Three hundred and five cases from 19 independent studies were included for review. Nine studies explored the outcomes from robotic-assisted esophagectomy and eight, the robotic-assisted gastrectomy. Two articles included small case series of both procedures. The level of evidence was predominantly based on case series or expert opinion (Level 4 or 5) with only three unmatched or poorly matched comparative trials (Level 4) with no randomized trials evident. Improved operative outcomes and hospital stays were demonstrated with a reduction of 2 days when the robotic-assisted gastrectomy technique was employed compared with the open. No improvement in oncological outcomes could be identified with the use of the robot for either oesophageal or gastric cancer resection; however, in terms of short-term oncological outcomes, these were at least equivalent to the open approach for oesophageal cancer and early stage gastric cancer. Robotic-assisted laparoscopic surgery is a feasible technique to use to perform a safe and oncologically sound resection for oesophageal and early gastric cancer. Operative benefits appear to be encouragingly similar to the laparoscopic approach with some demonstration of improvement over the open technique despite a prolonged operative time. However, the level of evidence is suboptimal and more randomized controlled trials and long-term survival studies within a framework of measured and comparable outcomes is required.


Subject(s)
Esophageal Neoplasms/surgery , Esophagectomy/methods , Gastrectomy/methods , Laparoscopy/methods , Robotics/methods , Stomach Neoplasms/surgery , Humans , Postoperative Complications , Treatment Outcome
14.
Clin Radiol ; 65(9): 708-19, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20696298

ABSTRACT

AIM: To determine the accuracy of computed tomography (CT) in detecting disease with invasion beyond the muscularis propria (MP) and malignant lymph nodes. MATERIALS AND METHODS: A literature search of Ovid, Embase, the Cochrane database, and Medline using Pubmed, Google Scholar and Vivisimo search engines was performed to identify studies reporting on the accuracy of CT to predict the staging of colonic tumours. Publication bias was demonstrated by Funnel plots. The sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated using a bivariate random effects model and hierarchical summary operating curves (HSROC) were generated. RESULTS: Nineteen studies fulfilled all the necessary inclusion criteria. The pooled sensitivity, specificity, DOR for detection of tumour invasion were 86% (95% CI: 78-92%); 78% (95% CI: 71-84%); 22.4 (95% CI: 11.9-42.4). Similarly, the values for nodal detection were 70% (95% CI: 63-73%); 78% (95% CI: 73-82%); 8.1(95% CI: 4.7-14.1). In the subgroup analysis, the best results were obtained in studies utilizing multidetector CT (MDCT). CONCLUSION: Preoperative staging CT accurately distinguishes between tumours confined to the bowel wall and those invading beyond the MP; however, it is significantly poorer at identifying nodal status. MDCT provides the best results.


Subject(s)
Colonic Neoplasms/diagnostic imaging , Neoplasm Staging , Tomography, X-Ray Computed/standards , Colonic Neoplasms/pathology , Humans , Lymphatic Metastasis , Odds Ratio
15.
Proc Inst Mech Eng H ; 224(6): 789-96, 2010.
Article in English | MEDLINE | ID: mdl-20608495

ABSTRACT

This is an explanatory article introducing the combination of various technologies used in implant and restorative dentistry. The aim of the article is to provide an overview of some of the techniques supporting the restorative treatment plan at various stages to provide contemporary, state-of-the-art bridgework based on dental implants. It is a discussion of the way existing technologies used in fields of engineering and medicine are brought together to form a complete process.


Subject(s)
Dental Implantation/trends , Dental Implants/trends , Dental Prosthesis/trends , Forecasting , Microsurgery/trends , Minimally Invasive Surgical Procedures/trends , Surgery, Computer-Assisted/trends , Biotechnology/trends
16.
Br J Cancer ; 102(9): 1327-34, 2010 Apr 27.
Article in English | MEDLINE | ID: mdl-20389297

ABSTRACT

BACKGROUND: The role of adjuvant chemotherapy after resection of colorectal cancers (CRCs) is well understood for patients with stage-I or stage-III disease. Its efficacy for those with stage-II disease remains much less clear. Many investigators have sought to identify prognostic markers that might clarify which patients have the highest risk of recurrence and would, therefore, be most likely to benefit from chemotherapy. This systematic review examines evidence for the use of peripherally sampled, circulating tumour cells (CTCs) as such a prognostic marker. METHODS: A comprehensive literature search was used to identify studies reporting on the significance of CTCs in the postoperative blood of CRC patients. RESULTS: Fourteen studies satisfied the inclusion criteria. Six of the nine studies that took blood samples 24 h or more postoperatively found detection of postoperative CTCs to be an independent predictor of cancer recurrence. CONCLUSION: The presence of CTCs in peripheral blood at least 24 h after resection of CRCs is an independent prognostic marker of recurrence. Further studies are needed to clarify the optimal time point for blood sampling and determine the benefit of chemotherapy in CTC-positive patients with stage-II disease.


Subject(s)
Colorectal Neoplasms/surgery , Prognosis , Aged , Carcinoembryonic Antigen/analysis , Chemotherapy, Adjuvant/methods , Colorectal Neoplasms/blood , Colorectal Neoplasms/diagnosis , Colorectal Neoplasms/drug therapy , Colorectal Neoplasms/pathology , Humans , Keratins/analysis , Middle Aged , Neoplasm Recurrence, Local/pathology , Neoplasm Recurrence, Local/surgery , Neoplasm Staging , Patient Selection , Postoperative Complications/epidemiology , Postoperative Complications/pathology , Recurrence , Treatment Outcome
17.
JSLS ; 13(3): 327-31, 2009.
Article in English | MEDLINE | ID: mdl-19793471

ABSTRACT

INTRODUCTION: Acute inguinal hernias are a common presentation as surgical emergencies, which have been routinely managed with open surgery. In recent years, the laparoscopic approach has been described by several authors but has been controversial amongst surgeons. We describe the laparoscopic approach to incarcerated/strangulated inguinal hernias based on a review of the literature with regards to its feasibility in laparoscopically managing the acute hernia presentation. METHODS: A systematic literature search was carried out including Medline with PubMed as the search engine, and Ovid, Embase, Cochrane Collaboration, and Google Scholar databases to identify articles reporting on laparoscopic treatment, reduction, and repair of incarcerated or strangulated inguinal hernias from 1989 to 2008. RESULTS: Forty-three articles were found, and 7 were included according to the inclusion criteria set. Articles reporting on the use of laparoscopy for the evaluation of the hernia but not reducing and repairing it, the use of the open technique, elective hernia repairs, pediatric series, review articles, and other kinds of hernias were excluded after title and abstract review. This resulted in 16 articles that were reviewed in full. Of these 16 articles, 7 reported on the use of the laparoscopic approach exclusively. From these 7 studies, there were 328 cases reported, 6 conversions, average operating time of 61.3 minutes (SD+/-12.3), average hospital stay of 3.8 days (SD+/-1.2), 34 complications (25 of which were reported as minor), and 17 bowel resections performed either laparoscopically or through a minilaparotomy incision guided laparoscopically. CONCLUSION: The laparoscopic repair is a feasible procedure with acceptable results; however, its efficacy needs to be studied further, ideally with larger multicenter randomized controlled trials.


Subject(s)
Hernia, Inguinal/surgery , Laparoscopy/methods , Humans , Intestines/blood supply , Length of Stay , Postoperative Complications , Recurrence , Safety
18.
Anaesthesia ; 64(8): 883-93, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19604193

ABSTRACT

This study reviews the predictive value of maximum oxygen consumption (VO2max) and anaerobic threshold, obtained through cardiopulmonary exercise testing, in calculating peri-operative morbidity and mortality in non-cardiopulmonary thoraco-abdominal surgery. A literature review provided nine studies that investigated either one or both of these two variables across a wide range of surgical procedures. Six of the seven studies that reported sufficiently detailed results on peak oxygen consumption and four of the six studies that reported sufficiently detailed results on anaerobic threshold found them to be significant predictors. We conclude that peak oxygen consumption and possibly anaerobic threshold are valid predictors of peri-operative morbidity and mortality in non-cardiopulmonary thoraco-abdominal surgery. These indicators could potentially provide a means of allocating increased care to high-risk patients.


Subject(s)
Exercise Test/methods , Health Status Indicators , Preoperative Care/methods , Anaerobic Threshold/physiology , Humans , Oxygen Consumption/physiology , Postoperative Complications , Prognosis , Risk Assessment/methods
19.
Neuroradiol J ; 22(1): 29-34, 2009 Mar 23.
Article in English | MEDLINE | ID: mdl-24206950

ABSTRACT

Moyamoya disease is a rare cerebrovascular occlusive disorder most often found among the Japanese. It is angiographically defined as a progressive steno-occlusion of the bilateral internal carotid arteries with characteristic abnormal vascular networks, so-called Moyamoya vessels, at the base of the brain. MRI is the initial investigation of choice and we describe an MRI sign to diagnose Moyamoya disease warranting digital subtraction angiography.

20.
Neurol India ; 56(2): 167-72, 2008.
Article in English | MEDLINE | ID: mdl-18688142

ABSTRACT

BACKGROUND: Scalp is the most common site of soft tissue arteriovenous fistulae and surgical excision has been the primary mode of treatment. Endovascular treatment has evolved as an alternative to the surgery. AIMS: To evaluate the effectiveness of percutaneous direct-puncture embolization of cirsoid aneurysms. MATERIALS AND METHODS: From January 1995 to December 2004, 15 patients underwent percutaneous direct-puncture embolization of cirsoid aneurysms. Plain X-ray, computerized tomography scan and complete selective cerebral angiogram were done in all. Seven patients had forehead lesions, four had temporal and the remaining four patients had occipital region cirsoid aneurysms. Lesions were punctured with 21-gauge needle and embolized with 20-50% cyanoacrylate-lipiodol mixture. Circumferential compression was applied during injection. RESULTS: Post-embolization angiogram showed complete obliteration in 11 patients. The remaining four patients required adjunctive transarterial embolization with polyvinyl alcohol particles for complete lesion devascularization. Two patients had post procedure surgery for removal of disfiguring and hard glue cast. There were no major procedure-related complications. No patients had any recurrence in the follow-up. CONCLUSION: Percutaneous direct puncture embolization of cirsoid aneurysms is a safe and effective procedure. It can be effectively used as an alternative to surgery. Sometimes adjunctive transarterial embolization is also required to deal with deeper feeders.


Subject(s)
Arteriovenous Fistula/therapy , Chemoembolization, Therapeutic/methods , Scalp/blood supply , Adolescent , Adult , Arteriovenous Fistula/diagnostic imaging , Cerebral Angiography/methods , Child , Enbucrilate/administration & dosage , Female , Humans , Injections , Male , Middle Aged , Punctures , Retrospective Studies , Tomography, X-Ray Computed/methods , Young Adult
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