ABSTRACT
Bone system was examined in 112 liquidators; in 71 of these osseous tissue density was studied by osseous densitometer using bienergetic x-ray absorptiometry and in 45 x-ray examinations, analyses of biochemical and hormonal parameters were carried out. Spinal painful syndrome was detected in 61 to 82% of the examinees. For analysis of densitometric and x-ray parameters the liquidators were divided into 2 groups: group 1 included those who worked at the power plant in 1986 (55%) and group 2 were those who worked there in 1987-1989. Radiation doses in group 1 reliably surpassed those in group 2 (p < 0.001). Bone mineral density in the lumbar vertebrae was significantly lower in group 1 as against group 2 and lower in both groups vs. controls. More than 5% osseous mineral loss was revealed in 73% of group 1 liquidators and in 43% of group 2 ones. Analysis of spinal roentgenograms in 45 liquidators showed a high incidence of negligible and moderately expressed osteoporosis without compression fractures of vertebral bodies: osteopenia signs were found in 87% of group 1 examinees complaining of pain in the spine and in 73% of group 2 examinees; signs of osteochondrosis and spondylosis were detected in 40% of group 1 and in 47% of group 2 subjects. Hence, a higher incidence of osteopenia in liquidators, more manifest condition and its higher detection rate in subjects exposed to higher radiation doses indicate a certain contribution of radiation factor to the development of the osteopenia syndrome in liquidators.
Subject(s)
Bone Diseases, Metabolic/etiology , Occupational Diseases/etiology , Power Plants , Radiation Injuries/etiology , Radioactive Hazard Release , Adult , Bone Density/radiation effects , Humans , Male , Middle Aged , Syndrome , UkraineABSTRACT
Normal values of bone mineral composition were defined, based on examinations of 600 male and female volunteers of various age groups by digital roentgenodensitometry. The mineral compactness was found reduced in the patients with endocrine diseases, in subjects who participated in liquidation of the Chernobyl power plant accident aftereffects, and in those suffering from skeletal pains. The authors emphasize the value of digital roentgenodensitometry as a method for monitoring the efficacy of treatment of patients with endocrine diseases and chronic renal insufficiency.
Subject(s)
Absorptiometry, Photon , Bone Density , Adolescent , Adult , Bone Diseases/diagnostic imaging , Bone Diseases/etiology , Female , Humans , Male , Middle Aged , Power Plants , Radioactive Hazard Release , UkraineABSTRACT
Sixteen women with hyperprolactinemia were examined for Ca metabolism, osseous metabolism, mineral saturation of bone tissue in the thoracic portion of the spine and radius. Lowered mineral saturation of the thoracic vertebrae was detected in 69% of the examinees, that of the distal segment of the radius in 44%. Reduction of the mineral saturation of the spine was in negative correlation with the blood prolactin level and length of amenorrhea. No changes in the bone resorption biochemistry or Ca metabolism were detected. A marked reduction of blood osteocalcin level that reflects osteoblast function was detected, its blood concentration being in negative correlation with prolactin level. No relationships between mineral saturation of bone tissue, prolactin, and osteocalcin, on the one hand, and blood estradiol level, on the other, were observed. These data suggest that osteopathy in hyperprolactinemic hypogonadism is due to reduced bone formation and not to reduced estradiol production.
