[Immunomorphological analysis of prolonged intoxication by low doses of herbicide simazine]. / Immunomorfologicheskii analiz dlitel'noi intoksikatsii malymi dozami gerbitsida simazina.

Dynamic investigation of several immunologic data and complex morphologic study of the thymus of rats fed for a long time (6 months) by very low doses of herbicide simazine have been carried out. Chronic simazine treatment resulted in the development of the secondary immunodeficient state with the damage of T lymphocytes. The morphologic signs of this process were the disarray in thymus structure (dystrophic changes and intercellular contact break of nurse cells, sclerosis of microvessel walls and stromal elements), severe decrease of the T lymphocyte number in peripheral blood, inhibition of phagocytosis reaction of neutrophils.

[The immunomorphological characteristics of a focal staphylococcal infection against a background of long-term exposure to low doses of simazine]. / Immunomorfologicheskaia kharakteristika ochagovoi stafilokokkovoi infektsii na fone dlitel'nogo vozdeistviia malykh doz simazina.

State of immunologic and nonspecific resistance of the organism, ultra- and histostructure of the thymus, histopathology of the wall of experimental staph abscess reproduced in animals given low doses of the herbicide simazine for a long time have been studied. It is established that simazine induced the immunodeficiency state underlain by pathologic changes in the thymus. Against this background experimental abscesses developed more rapidly, alterative and exudative processes in their wall proceeding more intensively and proliferative ones--attenuating. This provides prolongation of the abscesses healing phase for an indefinite time and chronization of the process.

[Ultrastructural changes in the adenohypophysis-thyroid system in chronic poisoning by the herbicide linuron]. / Ul'trastrukturnye izmeneniia v adenogipofizarno-tireoidnoi sisteme pri khronicheskom otravlenii gerbitsidom linuronom.

Ultrastructural adenohypophysis-thyroid system investigation of Wistar male rats under conditions of chronic poisoning by Linuron herbicide and administration of thymohemin immunomodulator was performed. The release of thyrocyte fragments into the vascular lumen, electron-dense deposits in the area of vascular basal membrane, dilatation of endoplasmic reticulum cisternae as well as inhibition of Golgi complex in thyrocytes are observed in the thyroid exposed to Linuron; in the adenohypophysis under the same conditions swelling and splitting of microvessel basal membrane as well as the increase of biosynthetic and secretory thyrotrophic function can be seen. Thymohemin reduces the degree of degenerative processes in the thyroid gland.

[The immunomorphological characteristics of prolonged exposure to the herbicide linuron]. / Immunomorfologicheskaia kharakteristika dlitel'nogo vozdeistviia gerbitsida linurona.

The authors investigated the effect of long-term use of the herbicide linuron on the histo- and ultrastructure of the thymus and factors of immunological defense. It was found that the use of linuron in animals resulted in development of secondary immunodeficiency states manifested in pathology of the thymic structure, first of all lesions of the epithelial cells-feeders and disorders of immunological indices.