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Eksp Klin Farmakol ; 67(3): 30-3, 2004.
Article in Russian | MEDLINE | ID: mdl-15341064

ABSTRACT

A series of four new furoxanopyrimidine derivatives was synthesized and studied with respect to antiulcerous, antisecretory, and antibacterial activity. Two compounds exhibit antiulcerous effect not accompanied (in contrast to the well-known H2 receptor blockers, quiditene, and other antiulcerous drugs) by inhibition of gastric acid secretion. No one of the studied compounds exhibited antibacterial activity in the tests with Helicobacter pylori.


Subject(s)
Anti-Ulcer Agents/therapeutic use , Oxadiazoles/pharmacology , Pyrimidines/pharmacology , Stomach Ulcer/drug therapy , Animals , Dose-Response Relationship, Drug , Gastric Mucosa/drug effects , Gastric Mucosa/metabolism , Helicobacter pylori/drug effects , Male , Nitric Oxide Donors/pharmacology , Rats , Stomach Ulcer/chemically induced , Stomach Ulcer/physiopathology
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