ABSTRACT
OBJECTIVE: To see whether patients with eating disorders consult general practitioners more frequently than control subjects and, if so, to describe the pattern of consultation. METHOD: General practitioner case record review of patients with anorexia nervosa, bulimia nervosa, and partial syndromes referred to a specialist eating disorder service. RESULTS: Seventy-eight of 100 case records were available for analysis. Eating disorder patients consulted significantly more frequently than controls over 5 years prior to the diagnosis of the eating disorder. They presented to the general practitioners with a variety of symptoms including psychological, gastrointestinal, and gynecological complaints. DISCUSSION: The findings suggest that methods could be developed to enable earlier diagnosis of eating disorders in general practice. This will enable the earlier application of effective treatments with the prospect of improved outcome.
Subject(s)
Feeding and Eating Disorders/diagnosis , Patient Acceptance of Health Care/statistics & numerical data , Patient Care Team/statistics & numerical data , Referral and Consultation/statistics & numerical data , Adolescent , Adult , Anorexia Nervosa/diagnosis , Anorexia Nervosa/epidemiology , Bulimia/diagnosis , Bulimia/epidemiology , Diagnosis, Differential , Family Practice/statistics & numerical data , Feeding and Eating Disorders/epidemiology , Female , Humans , Middle Aged , Scotland/epidemiology , Somatoform Disorders/diagnosis , Somatoform Disorders/epidemiology , Treatment OutcomeABSTRACT
During 2 years 27 cases of Yersinia pseudotuberculosis infections were diagnosed in the infectious ward. On the basis of literary data and her own cases the author discusses in details the clinical aspects and varying forms of Yersinia pseudotuberculosis infections. The attention is drawn to the fact that the pathogen is widespread, to the incidence of human infections and to the difficulties of differential diagnostics.
Subject(s)
Yersinia Infections/epidemiology , Yersinia pseudotuberculosis Infections/epidemiology , Adolescent , Animals , Bites and Stings/complications , Cats , Doxycycline/therapeutic use , Female , Humans , Insect Bites and Stings , Male , Yersinia pseudotuberculosis Infections/diagnosis , Yersinia pseudotuberculosis Infections/drug therapySubject(s)
Diabetes Complications , Hepatitis A/transmission , Hepatitis B/transmission , Hepatitis, Chronic/transmission , Injections/adverse effects , Diabetes Mellitus/drug therapy , Epidemiologic Methods , Equipment Contamination , Hepatitis A/epidemiology , Hepatitis B/epidemiology , Hepatitis C/epidemiology , Hepatitis C/transmission , Hepatitis, Chronic/epidemiology , Humans , Hungary , SyringesSubject(s)
Ecthyma, Contagious/etiology , Tumor Virus Infections/etiology , Animal Husbandry , Animals , Bovine papillomavirus 1 , Cattle , Cattle Diseases/microbiology , Ecthyma, Contagious/microbiology , Humans , Male , Middle Aged , Occupational Diseases/etiology , Sheep , Tumor Virus Infections/microbiology , ZoonosesABSTRACT
The molar ratio of menadione (vitamin K3) to beta-cyclodextrin in the microcrystalline inclusion complex showed this to be 1:3 with a menadione content of approximately 4.1-4.3%. Complexes with higher vitamin content could not be prepared. Bound and free vitamin can be readily separated by sublimation in vacuum. The menadione is highly stable in complexed form; in dry state it is released only when cyclodextrin is destroyed by heating to about 300 degrees C. Complexed menadione does not react with amino acids. Solubility and dissolution rate are strongly increased. Treating hypovitaminotic chickens with equivalent doses of menadione or menadione-beta-cyclodextrin complex and monitoring blood clotting times, recalcification times and prothrombin times the complex proved to be at least as effective as--or even somewhat more potent than--free vitamin. 1.5-2.0 micrograms/animal/d free or complexed menadione was sufficient to cover the daily vitamin K needs of chickens.
Subject(s)
Cyclodextrins/administration & dosage , Dextrins/administration & dosage , Starch/administration & dosage , Vitamin K/administration & dosage , beta-Cyclodextrins , Animals , Chemical Phenomena , Chemistry, Physical , Chickens , Crystallization , Cyclodextrins/pharmacology , Nephelometry and Turbidimetry , Poultry Diseases/drug therapy , Vitamin K/pharmacology , Vitamin K Deficiency/drug therapy , Vitamin K Deficiency/veterinaryABSTRACT
The compound CH-401-Na (1-[2-hydroxy-4-(3-sulphopropyloxy)phenyl]-3-[3-hydroxy-4-methoxyphenyl]-propanone-1-Na) was studied. Its sweeting power in aqueous solution is 1000 (as compared to that of a 1% sucrose solution); the values for salts formed with 10 other cations range from 750 to 1150. In contrast to the sweet taste of sucrose, that of CH-401-Na is perceived not at the tip of the tongue but at the root of the tongue and at both sides of the oral cavity. It persists for a longer period than that of sucrose. This effect depends to some extent on the cation. The addition of inorganic salts accelerates the extinction of sweet taste. In lemonades, almost 90% of sucrose may be replaced by CH-401-salts. The taste of CH-401-Na is unpleasant in foods having a bitter taste (coffee, cola) and in low-moisture products.
