1.
Modulation of human neutrophil functions in vitro by Treponema denticola major outer sheath protein.
Infect Immun
; 74(3): 1954-7, 2006 Mar.
Article
in English
| MEDLINE
| ID: mdl-16495573
ABSTRACT
In this study of human polymorphonuclear leukocytes (PMNs), pretreatment with Treponema denticola major outer sheath protein (Msp) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis, phagocytosis of immunoglobulin G-coated microspheres, fMLP-stimulated calcium transients, and actin assembly. Msp neither altered oxidative responses to phorbol myristate or fMLP nor induced apoptosis. Msp selectively impairs chemotaxis and phagocytosis by impacting the PMN cytoskeleton.