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[A modification of the bromsulphalein test for studying the excretory-absorptive function of the liver in rats]. / Modifikatsiia bromsul'faleinovoi proby dlia izucheniia ékskretorno-poglotitel'noi funktsii pecheni u krys.

Putiatina, T K; Aprosin, Iu D; Nedoshivina, R V.

Patol Fiziol Eksp Ter ; (6): 58-9, 1989.

Article in Russian | MEDLINE | ID: mdl-2628886

Subject(s)

Liver Function Tests/methods , Sulfobromophthalein , Animals , Mathematics , Rats , Sulfobromophthalein/metabolism , Time Factors

[Possible increase in the duration of the circulation of perfluorodecalin emulsions in the vascular bed of rats]. / O vozmozhnosti uvelicheniia dlitel'nosti tsirkuliatsii émul'sii perftordekalina v krovenosnom rusle krys.

Putiatina, T K; Aprosin, Iu D; Afonin, N I.

Gematol Transfuziol ; 33(5): 25-8, 1988 May.

Article in Russian | MEDLINE | ID: mdl-3410263

Subject(s)

Blood Circulation , Blood Substitutes/therapeutic use , Fluorocarbons/therapeutic use , Animals , Blood Substitutes/pharmacokinetics , Drug Combinations/administration & dosage , Emulsions , Fluorocarbons/blood , Half-Life , Particle Size , Phospholipids/administration & dosage , Rats , Sorbitol/administration & dosage , Time Factors

[Non-ionogenic surface-active agents as a component of oxygen carrying fluorocarbon blood substitutes]. / Neionogennye poverkhnostno-aktivnye veshchestva kak komponent krovezamenitelei--perenoschikov kisloroda na osnove ftoruglerodov.

Afonin, N I; Rybolovleva, Iu R; Putiatina, T K; Aprosin, Iu D; Doronina, N N.

Probl Gematol Pereliv Krovi ; 27(10): 12-4, 1982 Oct.

Article in Russian | MEDLINE | ID: mdl-7178045

Subject(s)

Blood Substitutes , Fluorocarbons , Surface-Active Agents/toxicity , Animals , Blood Viscosity/drug effects , Chemical Phenomena , Chemistry , Emulsions , In Vitro Techniques , Lethal Dose 50 , Mice , Mitochondria, Liver/metabolism , Rats , Structure-Activity Relationship

[Changes in lactate dehydrogenase activity and lactic and pyruvic acid concentration in the blood and tissues of animals following intravenous administration of perfluorotributylamine emulsions]. / Izmenenie aktivnosti laktatdegidrogenazy i soderzhaniia molochnoi i pirovinogradnoi kislot v krovi i tkaniakh zhivotnykh posle vnutrivennogo vvedeniia émul'sii perftortributilamina.

Afonin, N I; Doronina, N N; Smelova, O S; Ivanova, N L; Putiatina, T K.

Vopr Med Khim ; 26(2): 185-7, 1980.

Article in Russian | MEDLINE | ID: mdl-7456348

ABSTRACT

Activity of lactate dehydrogenase (LDH) and concentration of lactate and pyruvate were studied in rat and cat tissues after infusion of perfluorotributylamine emulsion. Administration of the emulsion caused an increase in content of lactate and pyruvate as well as LDH activation in the animal blood and tissues. Tissue hypoxia, responsible for stimulation of glycolytic pathway of carbohydrate metabolism, was apparently developed due to transfer of inadequate amount of oxygen by perfluorotributylamine.

Subject(s)

Blood Substitutes/pharmacology , Butylamines/pharmacology , Fluorocarbons/pharmacology , L-Lactate Dehydrogenase/metabolism , Lactates/analysis , Pyruvates/analysis , Animals , Cats , Kidney/metabolism , Liver/metabolism , Lung/metabolism , Myocardium/analysis , Rats , Species Specificity , Spleen/metabolism

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