1.
Eksp Klin Farmakol
; 57(6): 33-5, 1994.
Article
in Russian
| MEDLINE
| ID: mdl-7756956
ABSTRACT
The influence of the local anesthetics hydrocortisone hemisuccinate and peptide drugs (thymogen and dalargin) on Na-H exchange activity and passive proton permeability of the sarcolemma was studied in experiments on isolated rat hearts. It was established that neither local anesthetics or hydrocortisone hemisuccinate, nor peptide drugs affected Na-H exchange activity. Lidocaine (5 mM), procaine (5 mM), hydrocortisone hemisuccinate (500-750 mg/l) inhibited sarcolemmal passive proton permeability by 40-70%. Aetaphone in the micromolar range attenuated the role of these effects in the antiarrhythmic action of local anesthetics and aetaphone.
Subject(s)
Cell Membrane Permeability/drug effects , Heart/drug effects , Hydrogen/metabolism , Myocardium/metabolism , Protons , Sarcolemma/drug effects , Sodium/metabolism , Animals , Hydrogen-Ion Concentration , In Vitro Techniques , Perfusion/methods , Rats , Sarcolemma/metabolism , Time Factors
2.
Ortop Travmatol Protez
; 30(4): 76-8, 1969 Apr.
Article
in Russian
| MEDLINE
| ID: mdl-5372220