ABSTRACT
Thirty-year experience in surgical treatment of more than 3,000 patients with severe and moderately severe bronchial asthma showed that unilateral glomectomy produces a stable positive result in 69.5% of patients in follow-up repiods of two and more decades. Clinical recovery occurred in 23.2% of patients. Immunocorrection methods, such as hemosorption, plasmapheresis, plasmacytopheresis, xenosplenoperfusion, and the use of splenoperfusate raise the efficacy of the operation to 80-90%. The indications and contraindications for glomectomy in patients with bronchial asthma and methods for immunocorrection treatment of patients after glomectomy were developed.
Subject(s)
Asthma/surgery , Carotid Body/surgery , Anesthesia, Local , Antigen-Antibody Complex/immunology , Asthma/immunology , Asthma/physiopathology , Contraindications , Follow-Up Studies , Hemodynamics , Humans , Immunoglobulin E/immunology , Immunoglobulin G/immunology , Postoperative Care , Preoperative Care , Respiration , Severity of Illness Index , Sorption Detoxification/methods , Surgical Procedures, OperativeABSTRACT
Blood morphology, external respiratory function, central hemodynamics, cellular and humoral immunity, circulating immune complexes, average molecules and leucocytic index were examined in 40 patients with a severe and average severe course of infection-dependent bronchial asthma before and after xenosplenoperfusion. Positive clinical results were noted manifested in an increase of the immune reactivity, improvement of external respiratory function. The method should be used with care due to additional sensibilization of the patient and possible bronchospasm.