ABSTRACT
Anabolic-androgenic steroid (AAS) use is common among young males, including adolescents. There have been several anecdotal reports of severe cardiovascular events in self-reported young users of AAS, including acute myocardial infarction, sudden cardiac death, and cardiomyopathy. We present an additional case of a young male weight lifter who presented with dyspnea and chest pain attributable to dilated cardiomyopathy (DC), his only known risk factor being the recent use of AAS. The possible role of AAS in the development of DC is discussed.
Subject(s)
Anabolic Agents/adverse effects , Cardiomyopathy, Dilated/chemically induced , Weight Lifting , Adult , Anabolic Agents/administration & dosage , Dose-Response Relationship, Drug , Drug Administration Schedule , Drug Combinations , Drug Therapy, Combination , Electrocardiography/drug effects , Humans , Male , Testosterone/administration & dosage , Testosterone/adverse effects , Testosterone/analogs & derivativesABSTRACT
3 ketone solvents (methyl ethyl ketone (MEK), methyl isobutyl ketone (MiBK), and isophorone) were tested for potential genotoxicity. The assays of MEK and MiBK included the Salmonella/microsome (Ames) assay, L5178Y/TK+/- mouse lymphoma (ML) assay, BALB/3T3 cell transformation (CT) assay, unscheduled DNA synthesis (UDS) assay, and micronucleus (MN) assay. Only the ML, UDS, and MN assays were conducted on samples of isophorone. No genotoxicity was found for MEK or isophorone. The presence of a marginal response only at the highest, cytotoxic concentration tested in the ML assay, the lack of reproducibility in the CT assay, and clearly negative results in the Ames assay, UDS and MN assays, suggest that MiBK is unlikely to be genotoxic in mammalian systems.
